Effectiveness of hydroalcoholic extract of Nasturtium Officinale on sleep quality, asthma control and quality of life in asthmatic patients: a randomized controlled trial
-
Reza Abbasi Abbasi
,
Ezzat Zarei
,
Nasrin Shakerinasab
,
Mahdieh Eftekhari
,
Hossein Sadeghi
,
Ali Fazel
,
Amir-Hossein Doustimotlagh
,
Fatemeh Bazarganipour
Abstract
Objective: Considering the role of oxidants in asthma, airway inflammation and anti-inflammatory effects of Nasturtium officinale extract, the present study aimed to investigate the impact of hydroalcoholic extract of Nasturtium officinale on sleep quality, asthma control, and quality of life in asthmatic patients.
Methods: This was a parallel group randomized clinical trial undertaken in Yasuj, Iran. It included 60 patients who randomly received either Nasturtium officinale hydroalcoholic extract (500 mg daily, four weeks, and orally plus routine care) or placebo (500 mg capsule containing flour daily, four weeks, orally plus routine care. To achieve the study objectives, lung function (FEV1, FVC, PEF, FEF 25-75%, and FEV1/FVC), quality of life as measured by the 12-item Short Form Health Survey (SF-12), sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI), and asthma control as examined by the Asthma Control Test (ACT) were assessed at baseline and one-month follow-up.
Results: In all 48 patients (22 patients in intervention group and 26 patients as controls) completed the study. The results obtained from analyses showed no significant differences between the two groups regarding changes in lung function, quality of life, sleep quality, and status of asthma control within a one-month follow-up.
Conclusion: The findings suggest that hydroalcoholic extract of Nasturtium Officinale does not appear to improve sleep quality, asthma control, and quality of life in asthmatic patients in short term
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6. Bateman E. D., Boushey H. A., Bousquet J., et al. Can guideline-defined asthma control be achieved? The gaining optimal asthma control study. American Journal of Respiratory and Critical Care Medicine. 2004;170(8):836–844. doi: 10.1164/rccm.200401-033oc.
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8. Sy C. B., Siracusa M. C. The therapeutic potential of targeting cytokine allarmins to treat allergic airway inflammation. Frontiers in Physiology. 2016;7, article 214.
9. Ohta K., Ichinose M., Tohda Y., et al. Long-term once-daily tiotropium Respimat® is well tolerated and maintains efficacy over 52 weeks in patients with symptomatic asthma in Japan: a randomised, placebo-controlled study. PLoS ONE. 2015;10(4) doi: 10.1371/journal.pone.0124109.e0124109.
10. Lai T., Wang S., Xu Z., et al. Long-term efficacy and safety of omalizumab in patients with persistent uncontrolled allergic asthma: a systematic review and meta-analysis. Scientific Reports. 2015;5, article 8191
11. Ko J., Lee J. I., Muñoz-Furlong A., Li X.-M., Sicherer S. H. Use of complementary and alternative medicine by food-allergic patients. Annals of Allergy, Asthma and Immunology. 2006;97(3):365–369. doi: 10.1016/s1081-1206(10)60802-2.
12. Bielory L., Russin J., Zuckerman G. B. Clinical efficacy, mechanisms of action, and adverse effects of complementary and alternative medicine therapies for asthma. Allergy and Asthma Proceedings. 2004;25(5):283–291.
13. N. Azarmehr, P. Afshar, M. Moradi et al., “Hepatoprotective and antioxidant activity of watercress extract on acetaminophen-induced hepatotoxicity in rats,” Heliyon, vol. 5, no. 7, Article ID e02072, 2019.
14. J. P. Schuchardt, “Watercress–cultivation methods and health effects,” Journal of Applied Botany and Food Quality, vol. 92, no. 92, pp. 232–239, 2019.
15. N. Omidifar, A. Nili-Ahmadabadi, A. Nakhostin-Ansari et al., “The modulatory potential of herbal antioxidants against oxidative stress and heavy metal pollution: plants against environmental oxidative stress,” Environmental Science and Pollution Research, vol. 28, no. 44, pp. 61908–61918, 2021.
16. H. Sadeghi, N. Azarmehr, F. Razmkhah et al., “The hydroalcoholic extract of watercress attenuates protein oxidation, oxidative stress, and liver damage after bile duct ligation in rats,” Journal of Cellular Biochemistry, vol. 120, no. 9, pp. 14875–14884, 2019.
17. Lau, B.H., S.K. Riesen, K.P. Truong, E.W. Lau, P. Rohdewald, and R.A. Barreta, Pycnogenol® as an adjunct in the management of childhood asthma. Journal of Asthma, 2004. 41(8): p. 825-832.
18. Koshak, A., L. Wei, E. Koshak, S. Wali, O. Alamoudi, A. Demerdash, et al., Nigella sativa supplementation improves asthma control and biomarkers: A randomized, double‐blind, placebo‐controlled trial. Phytotherapy Research, 2017. 31(3): p. 403-409.
19. Sigari, N., N. Sigari, H. Ghasri, E. Rahimi, and S. Mohammadi, Validation of Persian version of asthma control test based on new global initiative for asthma guidelines. Tanaffos, 2011. 10(4): p. 49.
20. Jafarzadeh, L., A. Asgari, F. Golshan-Iranpoor, S. Kheiri, N. Parvin, M. Rafieian, et al., Abortificient effects of Stachys lavandulifolia Vahl in mice. Journal of Shahrekord Uuniversity of Medical Sciences, 2010. 11(4): p. 26-31.
21. Buysse, D.J., C.F. Reynolds, 3rd, T.H. Monk, S.R. Berman, and D.J. Kupfer, The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res, 1989. 28(2): p. 193-213.
22. Rezaei, E., Z.B. Moghadam, and K. Saraylu, Quality of life in pregnant women with sleep disorder. J Family Reprod Health, 2013. 7(2): p. 87-93.
23. Singh, A., K. Gnanalingham, A. Casey, and A. Crockard, Quality of life assessment using the Short Form-12 (SF-12) questionnaire in patients with cervical spondylotic myelopathy: comparison with SF-36. Spine (Phila Pa 1976), 2006. 31(6): p. 639-43.
24. Montazeri, A., M. Vahdaninia, S.J. Mousavi, and S. Omidvari, The Iranian version of 12-item Short Form Health Survey (SF-12): factor structure, internal consistency and construct validity. BMC Public Health, 2009. 9: p. 341.
25. Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, et al. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol. 2004;113:59–65.
26. National Heart, Lung, and Blood Institute. Expert panel report 3: guidelines for the diagnosis and management of asthma. 2007. https://www.nhlbi.nih.gov/files/docs/guidelines/asthgdln.pdf. Accessed 26 June 2018.
27. Sigari N, Sigari N, Ghasri H, Rahimi E, Mohammadi S. Validation of Persian Version of Asthma Control Test Based on new Global Initiative for Asthma Guidelines. Tanaffos. 2011;10(4):49-53. PMID: 25191388; PMCID: PMC4153175.
28. Sills, J.M., World Health Organization Adverse Reaction Terminology Dictionary. Drug Information Journal, 1989. 23(2): p. 211-216.
29. Miller M. R., Hankinson J., Brusasco V., et al. Standardisation of spirometry. European Respiratory Journal. 2005;26(2):319–338. doi: 10.1183/09031936.05.00034805.
30. N. Omidifar, N.-A. Amir, A. Gholami, D. Dara, A. Davoud, and N.-A. Hossein, “Biochemical and histological evidence on the protective effects of Allium hirtifolium boiss (persian shallot) as an herbal supplement in cadmium-induced hepatotoxicity,” Evidence-Based Complementary and Alternative Medicine, vol. 2020, Article ID 7457504, 8 pages, 2020.
31. JUNIPER, E.F.; WISNIEWSKI, M.E.; COX, F.M.; EMMETT,A.H.; NIELSEN, K.E.; O’BYRNE, P.M. Relationship between quality of life and clinical status in asthma: a factor analysis. Eur. Respir. J., v.23, n.2, p.287-291, 2004.
32. Wang Z., Yang J., Gong X. Effects of Qingfei Pingchuan Bushen Granules on 144 cases of asthma mild duration. China Journal of Traditional Chinese Medicine and Pharmacy. 2013;28:351–353.
33. Choi J.-S., Jang A.-S., Lee J.-H., et al. Effect of high dose inhaled glucocorticoids on quality of life in patients with moderate to severe asthma. Journal of Korean Medical Science. 2005;20(4):586–590. doi: 10.3346/jkms.2005.20.4.586.
34. Turner S., Eastwood P., Cook A., Jenkins S. Improvements in symptoms and quality of life following exercise training in older adults with moderate/severe persistent asthma. Respiration. 2011;81(4):302–310. doi: 10.1159/000315142.
35. Haughney J, Price D, Kaplan A, Chrystyn H, Horne R, May N, Moffat M, Versnel J, Shanahan ER, Hillyer EV, Tunsater A, Bjermer L. Achieving asthma control in practice: understanding the reasons for poor control. Respir Med. 2008;102:1681–1693.
36. Braido F, Baiardini I, Ghiglione V, Fassio O, Bordo A, Cauglia S, Canonica GW. Sleep disturbances and asthma control: a real life study. Asian Pac J Allergy Immunol. 2008;27:27–33.
37. Mastronarde JG, Wise RA, Shade DM, Olopade CO, Scharf SM. Sleep quality in asthma: results of a large prospective clinical trial. J Asthma. 2008;45:183–189.
38. Gill, C.I., S. Haldar, L.A. Boyd, R. Bennett, J. Whiteford, M. Butler, et al., Watercress supplementation in diet reduces lymphocyte DNA damage and alters blood antioxidant status in healthy adults. The American journal of clinical nutrition, 2007. 85(2): p. 504-510.
39. T.-I. Adam-Bonci, E. A. Bonci, A. E. Parvu et al., “Vitamin D supplementation: oxidative stress modulation in a mouse model of ovalbumin-induced acute asthmatic airway inflammation,” International Journal of Molecular Sciences, vol. 22, no. 13, p. 7089, 2021.
40. W.-C. Huang, N.-C. Ting, Y.-L. Huang, L.-C. Chen, C.-F. Lin, and C.-J. Liou, “Helminthostachys zeylanica water extract ameliorates airway hyperresponsiveness and eosinophil infiltration by reducing oxidative stress and Th2 cytokine production in a mouse asthma model,” Mediators of Inflammation, vol. 2020, Article ID 1702935, 15 pages, 2020.
41. W.-C. Huang, C. Y. Liu, S. C. Shen et al., “Protective effects of licochalcone A improve airway hyper-responsiveness and oxidative stress in a mouse model of asthma,” Cells, vol. 8, no. 6, p. 617, 2019.
42. M. Malaquias, L. Oyama, P. Jerico et al., “Effects of mesenchymal stromal cells play a role the oxidant/antioxidant balance in a murine model of asthma,” Allergologia et Immunopathologia, vol. 46, no. 2, pp. 136–143, 2018.
43. Thomas M, Sheran J, Smith N, Fonseca S, Lee AJ. AKL1, a botanical mixture for the treatment of asthma: a randomised, double-blind, placebo-controlled, cross-over study. BMC Pulm Med. 2007 Mar 20;7:4. doi: 10.1186/1471-2466-7-4. PMID: 17374147; PMCID: PMC1847837.
44. KELLY-PIEPER, K.; PATIL, S.P.; BUSSE, P.; YANG, N.;SAMPSON, H.; LI, X.M.; WISNIVESKY, J.P.; KATTAN,M. Safety and tolerability of an antiasthma herbal Formulam(ASHMI) in adult subjects with asthma: a randomized,double-blinded, placebo-controlled, dose-escalation phaseI study. J. Altern. Complement. Med., v.15, n.7, p.735-743,2009.
45. WONG, E.L.; SUNG, R.Y.; LEUNG, T.F.; WONG, Y.O.; LI,A.M.; CHEUNG, K.L.; WONG, C.K.; FOK, T.F.; LEUNG,P.C. Randomized, double-blind, placebo-controlled trial of herbal therapy for children with asthma. J. Altern.Complement Med., v.15, n.10, p.1091-1097, 2009.
46. ZHOU, T.N.; TANG, L.H.; HUANG, S.C.; LU, D.D.; WANG,Y.; LIU, L.F.; LAI, P.; YE, M.R. Study on the antitussive and antiasthmatic effects of Radix Fici Hirtae. Zhong. Yao Cai, v.32, n.4, p.571-574, 2009.
47. Clemente M, Miguel MD, Felipe KB, Gribner C, Moura PF, Rigoni AGR, Fernandes LC, Carvalho JLS, Hartmann I, Piltz MT, Henneberg R, Montrucchio DP, Miguel OG. Acute and sub-acute oral toxicity studies of standardized extract of Nasturtium officinale in Wistar rats. Regul Toxicol Pharmacol. 2019 Nov;108:104443. doi: 10.1016/j.yrtph.2019.104443. Epub 2019 Aug 19. PMID: 31437473.
48. Khosro Rafaie Shirpak, Maryam Chinichian, Hasasan Eftekhar, and Ali Ramezankhani, Need assessment: Sexual health education in family planning centers, Tehran, Iran. Health Monitor Journal of the Iranian Institute for Health Sciences Research, 2010. 9(3): p. 251-260.
2. Marks, G.B.; Mellis, C.M.; Peat, J.K.; Woolcock, A.J.;Leeder, S.R. A Profile of Asthma and Its Management in a New South Wales Provincial Centre. Med. J. Aust. 1994,160, 260–268.
3. Australian Centre for Asthma Monitoring. Asthma in Australia 2011. Canberra, Australia: AIHW; 2011. (AIHW Asthma series no 4. Cat.no. ACM 22).
4. Cazzola M, Rogliani P, Ora J, et al. Asthma and comorbidities: recent advances. Pol Arch Intern Med. 2022; 132: 16250. doi:10.20452/pamw.16250.
5. Juniper E. F., Wisniewski M. E., Cox F. M., Emmett A. H., Nielsen K. E., O'Byrne P. M. Relationship between quality of life and clinical status in asthma: a factor analysis. European Respiratory Journal. 2004;23(2):287–291. doi: 10.1183/09031936.04.00064204.
6. Bateman E. D., Boushey H. A., Bousquet J., et al. Can guideline-defined asthma control be achieved? The gaining optimal asthma control study. American Journal of Respiratory and Critical Care Medicine. 2004;170(8):836–844. doi: 10.1164/rccm.200401-033oc.
7. Partridge M. R., Dal Negro R. W., Olivieri D. Understanding patients with asthma and COPD: insights from a European study. Primary Care Respiratory Journal. 2011;20(3):315–323. doi: 10.4104/pcrj.2011.00056.
8. Sy C. B., Siracusa M. C. The therapeutic potential of targeting cytokine allarmins to treat allergic airway inflammation. Frontiers in Physiology. 2016;7, article 214.
9. Ohta K., Ichinose M., Tohda Y., et al. Long-term once-daily tiotropium Respimat® is well tolerated and maintains efficacy over 52 weeks in patients with symptomatic asthma in Japan: a randomised, placebo-controlled study. PLoS ONE. 2015;10(4) doi: 10.1371/journal.pone.0124109.e0124109.
10. Lai T., Wang S., Xu Z., et al. Long-term efficacy and safety of omalizumab in patients with persistent uncontrolled allergic asthma: a systematic review and meta-analysis. Scientific Reports. 2015;5, article 8191
11. Ko J., Lee J. I., Muñoz-Furlong A., Li X.-M., Sicherer S. H. Use of complementary and alternative medicine by food-allergic patients. Annals of Allergy, Asthma and Immunology. 2006;97(3):365–369. doi: 10.1016/s1081-1206(10)60802-2.
12. Bielory L., Russin J., Zuckerman G. B. Clinical efficacy, mechanisms of action, and adverse effects of complementary and alternative medicine therapies for asthma. Allergy and Asthma Proceedings. 2004;25(5):283–291.
13. N. Azarmehr, P. Afshar, M. Moradi et al., “Hepatoprotective and antioxidant activity of watercress extract on acetaminophen-induced hepatotoxicity in rats,” Heliyon, vol. 5, no. 7, Article ID e02072, 2019.
14. J. P. Schuchardt, “Watercress–cultivation methods and health effects,” Journal of Applied Botany and Food Quality, vol. 92, no. 92, pp. 232–239, 2019.
15. N. Omidifar, A. Nili-Ahmadabadi, A. Nakhostin-Ansari et al., “The modulatory potential of herbal antioxidants against oxidative stress and heavy metal pollution: plants against environmental oxidative stress,” Environmental Science and Pollution Research, vol. 28, no. 44, pp. 61908–61918, 2021.
16. H. Sadeghi, N. Azarmehr, F. Razmkhah et al., “The hydroalcoholic extract of watercress attenuates protein oxidation, oxidative stress, and liver damage after bile duct ligation in rats,” Journal of Cellular Biochemistry, vol. 120, no. 9, pp. 14875–14884, 2019.
17. Lau, B.H., S.K. Riesen, K.P. Truong, E.W. Lau, P. Rohdewald, and R.A. Barreta, Pycnogenol® as an adjunct in the management of childhood asthma. Journal of Asthma, 2004. 41(8): p. 825-832.
18. Koshak, A., L. Wei, E. Koshak, S. Wali, O. Alamoudi, A. Demerdash, et al., Nigella sativa supplementation improves asthma control and biomarkers: A randomized, double‐blind, placebo‐controlled trial. Phytotherapy Research, 2017. 31(3): p. 403-409.
19. Sigari, N., N. Sigari, H. Ghasri, E. Rahimi, and S. Mohammadi, Validation of Persian version of asthma control test based on new global initiative for asthma guidelines. Tanaffos, 2011. 10(4): p. 49.
20. Jafarzadeh, L., A. Asgari, F. Golshan-Iranpoor, S. Kheiri, N. Parvin, M. Rafieian, et al., Abortificient effects of Stachys lavandulifolia Vahl in mice. Journal of Shahrekord Uuniversity of Medical Sciences, 2010. 11(4): p. 26-31.
21. Buysse, D.J., C.F. Reynolds, 3rd, T.H. Monk, S.R. Berman, and D.J. Kupfer, The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res, 1989. 28(2): p. 193-213.
22. Rezaei, E., Z.B. Moghadam, and K. Saraylu, Quality of life in pregnant women with sleep disorder. J Family Reprod Health, 2013. 7(2): p. 87-93.
23. Singh, A., K. Gnanalingham, A. Casey, and A. Crockard, Quality of life assessment using the Short Form-12 (SF-12) questionnaire in patients with cervical spondylotic myelopathy: comparison with SF-36. Spine (Phila Pa 1976), 2006. 31(6): p. 639-43.
24. Montazeri, A., M. Vahdaninia, S.J. Mousavi, and S. Omidvari, The Iranian version of 12-item Short Form Health Survey (SF-12): factor structure, internal consistency and construct validity. BMC Public Health, 2009. 9: p. 341.
25. Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, et al. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol. 2004;113:59–65.
26. National Heart, Lung, and Blood Institute. Expert panel report 3: guidelines for the diagnosis and management of asthma. 2007. https://www.nhlbi.nih.gov/files/docs/guidelines/asthgdln.pdf. Accessed 26 June 2018.
27. Sigari N, Sigari N, Ghasri H, Rahimi E, Mohammadi S. Validation of Persian Version of Asthma Control Test Based on new Global Initiative for Asthma Guidelines. Tanaffos. 2011;10(4):49-53. PMID: 25191388; PMCID: PMC4153175.
28. Sills, J.M., World Health Organization Adverse Reaction Terminology Dictionary. Drug Information Journal, 1989. 23(2): p. 211-216.
29. Miller M. R., Hankinson J., Brusasco V., et al. Standardisation of spirometry. European Respiratory Journal. 2005;26(2):319–338. doi: 10.1183/09031936.05.00034805.
30. N. Omidifar, N.-A. Amir, A. Gholami, D. Dara, A. Davoud, and N.-A. Hossein, “Biochemical and histological evidence on the protective effects of Allium hirtifolium boiss (persian shallot) as an herbal supplement in cadmium-induced hepatotoxicity,” Evidence-Based Complementary and Alternative Medicine, vol. 2020, Article ID 7457504, 8 pages, 2020.
31. JUNIPER, E.F.; WISNIEWSKI, M.E.; COX, F.M.; EMMETT,A.H.; NIELSEN, K.E.; O’BYRNE, P.M. Relationship between quality of life and clinical status in asthma: a factor analysis. Eur. Respir. J., v.23, n.2, p.287-291, 2004.
32. Wang Z., Yang J., Gong X. Effects of Qingfei Pingchuan Bushen Granules on 144 cases of asthma mild duration. China Journal of Traditional Chinese Medicine and Pharmacy. 2013;28:351–353.
33. Choi J.-S., Jang A.-S., Lee J.-H., et al. Effect of high dose inhaled glucocorticoids on quality of life in patients with moderate to severe asthma. Journal of Korean Medical Science. 2005;20(4):586–590. doi: 10.3346/jkms.2005.20.4.586.
34. Turner S., Eastwood P., Cook A., Jenkins S. Improvements in symptoms and quality of life following exercise training in older adults with moderate/severe persistent asthma. Respiration. 2011;81(4):302–310. doi: 10.1159/000315142.
35. Haughney J, Price D, Kaplan A, Chrystyn H, Horne R, May N, Moffat M, Versnel J, Shanahan ER, Hillyer EV, Tunsater A, Bjermer L. Achieving asthma control in practice: understanding the reasons for poor control. Respir Med. 2008;102:1681–1693.
36. Braido F, Baiardini I, Ghiglione V, Fassio O, Bordo A, Cauglia S, Canonica GW. Sleep disturbances and asthma control: a real life study. Asian Pac J Allergy Immunol. 2008;27:27–33.
37. Mastronarde JG, Wise RA, Shade DM, Olopade CO, Scharf SM. Sleep quality in asthma: results of a large prospective clinical trial. J Asthma. 2008;45:183–189.
38. Gill, C.I., S. Haldar, L.A. Boyd, R. Bennett, J. Whiteford, M. Butler, et al., Watercress supplementation in diet reduces lymphocyte DNA damage and alters blood antioxidant status in healthy adults. The American journal of clinical nutrition, 2007. 85(2): p. 504-510.
39. T.-I. Adam-Bonci, E. A. Bonci, A. E. Parvu et al., “Vitamin D supplementation: oxidative stress modulation in a mouse model of ovalbumin-induced acute asthmatic airway inflammation,” International Journal of Molecular Sciences, vol. 22, no. 13, p. 7089, 2021.
40. W.-C. Huang, N.-C. Ting, Y.-L. Huang, L.-C. Chen, C.-F. Lin, and C.-J. Liou, “Helminthostachys zeylanica water extract ameliorates airway hyperresponsiveness and eosinophil infiltration by reducing oxidative stress and Th2 cytokine production in a mouse asthma model,” Mediators of Inflammation, vol. 2020, Article ID 1702935, 15 pages, 2020.
41. W.-C. Huang, C. Y. Liu, S. C. Shen et al., “Protective effects of licochalcone A improve airway hyper-responsiveness and oxidative stress in a mouse model of asthma,” Cells, vol. 8, no. 6, p. 617, 2019.
42. M. Malaquias, L. Oyama, P. Jerico et al., “Effects of mesenchymal stromal cells play a role the oxidant/antioxidant balance in a murine model of asthma,” Allergologia et Immunopathologia, vol. 46, no. 2, pp. 136–143, 2018.
43. Thomas M, Sheran J, Smith N, Fonseca S, Lee AJ. AKL1, a botanical mixture for the treatment of asthma: a randomised, double-blind, placebo-controlled, cross-over study. BMC Pulm Med. 2007 Mar 20;7:4. doi: 10.1186/1471-2466-7-4. PMID: 17374147; PMCID: PMC1847837.
44. KELLY-PIEPER, K.; PATIL, S.P.; BUSSE, P.; YANG, N.;SAMPSON, H.; LI, X.M.; WISNIVESKY, J.P.; KATTAN,M. Safety and tolerability of an antiasthma herbal Formulam(ASHMI) in adult subjects with asthma: a randomized,double-blinded, placebo-controlled, dose-escalation phaseI study. J. Altern. Complement. Med., v.15, n.7, p.735-743,2009.
45. WONG, E.L.; SUNG, R.Y.; LEUNG, T.F.; WONG, Y.O.; LI,A.M.; CHEUNG, K.L.; WONG, C.K.; FOK, T.F.; LEUNG,P.C. Randomized, double-blind, placebo-controlled trial of herbal therapy for children with asthma. J. Altern.Complement Med., v.15, n.10, p.1091-1097, 2009.
46. ZHOU, T.N.; TANG, L.H.; HUANG, S.C.; LU, D.D.; WANG,Y.; LIU, L.F.; LAI, P.; YE, M.R. Study on the antitussive and antiasthmatic effects of Radix Fici Hirtae. Zhong. Yao Cai, v.32, n.4, p.571-574, 2009.
47. Clemente M, Miguel MD, Felipe KB, Gribner C, Moura PF, Rigoni AGR, Fernandes LC, Carvalho JLS, Hartmann I, Piltz MT, Henneberg R, Montrucchio DP, Miguel OG. Acute and sub-acute oral toxicity studies of standardized extract of Nasturtium officinale in Wistar rats. Regul Toxicol Pharmacol. 2019 Nov;108:104443. doi: 10.1016/j.yrtph.2019.104443. Epub 2019 Aug 19. PMID: 31437473.
48. Khosro Rafaie Shirpak, Maryam Chinichian, Hasasan Eftekhar, and Ali Ramezankhani, Need assessment: Sexual health education in family planning centers, Tehran, Iran. Health Monitor Journal of the Iranian Institute for Health Sciences Research, 2010. 9(3): p. 251-260.
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| Issue | Vol 2 No 1 (2024) | |
| Section | Original Articles | |
| DOI | https://doi.org/10.18502/abi.v2i1.16247 | |
| Keywords | ||
| asthma quality of sleep asthma control quality of life Nasturtium officinale | ||
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How to Cite
1.
Abbasi RA, Zarei E, Shakerinasab N, Eftekhari M, Sadeghi H, Fazel A, Doustimotlagh A-H, Bazarganipour F. Effectiveness of hydroalcoholic extract of Nasturtium Officinale on sleep quality, asthma control and quality of life in asthmatic patients: a randomized controlled trial. ABI. 2024;2(1):52-60.
