Tehran University of Medical Sciences Acta Biochimica Iranica 0001-5261 2 1 2024 03 22 52 60 Reza Abbasi Abbasi Medicinal plants Research Center, Yasuj University of Medical Sciences, Yasuj Iran Ezzat Zarei Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran. Nasrin Shakerinasab Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran. Mahdieh Eftekhari Medicinal plants Research Center, Yasuj University of Medical Sciences, Yasuj Iran Hossein Sadeghi Medicinal plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran. Ali Fazel Medicinal plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran. Amir-Hossein Doustimotlagh Medicinal plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran. Fatemeh Bazarganipour Medicinal plants Research Center, Yasuj University of Medical Sciences, Yasuj, iran. 2024 05 22 Objective: Considering the role of oxidants in asthma, airway inflammation and anti-inflammatory effects of Nasturtium officinale extract, the present study aimed to investigate the impact of hydroalcoholic extract of Nasturtium officinale on sleep quality, asthma control, and quality of life in asthmatic patients. Methods: This was a parallel group randomized clinical trial undertaken in Yasuj, Iran. It included 60 patients who randomly received either Nasturtium officinale hydroalcoholic extract (500 mg daily, four weeks, and orally plus routine care) or placebo (500 mg capsule containing flour daily, four weeks, orally plus routine care. To achieve the study objectives, lung function (FEV1, FVC, PEF, FEF 25-75%, and FEV1/FVC), quality of life as measured by the 12-item Short Form Health Survey (SF-12), sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI), and asthma control as examined by the Asthma Control Test (ACT) were assessed at baseline and one-month follow-up. Results: In all 48 patients (22 patients in intervention group and 26 patients as controls) completed the study. The results obtained from analyses showed no significant differences between the two groups regarding changes in lung function, quality of life, sleep quality, and status of asthma control within a one-month follow-up. Conclusion: The findings suggest that hydroalcoholic extract of Nasturtium Officinale does not appear to improve sleep quality, asthma control, and quality of life in asthmatic patients in short term https://abi.tums.ac.ir/index.php/abi/article/view/86 https://abi.tums.ac.ir/index.php/abi/article/download/86/52