Serum CTRP1 Levels in Candidates for Coronary Artery Bypass Graft
CTRP1 Levels in Coronary Artery Bypass Graft
-
Asie Sadeghi
,
Hossein Pourghadamyari
,
Zohreh Ramazani-Karim
,
Mohammad Hajializadeh
,
Esmaeil Sajadi Moghadam
,
Hossein Borji
,
Hadis Ahmadirad
Abstract
Background: CTRP1 is an adipokine that plays crucial roles in the cardiovascular system, and its dysregulation has been reported in patients with CAD. In this study, our aim was to measure its levels in patients who were candidates for cardiac bypass surgery.
Methods: The participants consisted of 30 candidates for coronary artery bypass graft (CABG) surgery and an additional 30 controls. Inflammatory parameters were assessed using enzyme-linked immunosorbent assay (ELISA) kits. Serum CTRP1 concentration was determined using a commercially available ELISA kit.
Results: Serum CTRP1 levels significantly increased in the patient group compared to the control group (p-value < 0.0001). Furthermore, CTRP1 levels positively correlated with inflammatory parameters.
Conclusion: Elevated levels of CTRP1, along with inflammation in CAD, suggest the involvement of CTRP1 in inflammatory responses. However, this hypothesis remains to be fully elucidated.
Keywords: Coronary artery bypass graft; CTRP1; IL-6; TNF-α; hs-CRP
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15. Han S, Jeong AL, Lee S, Park JS, Buyanravjikh S, Kang W, et al. C1q/TNF-α–related protein 1 (CTRP1) maintains blood pressure under dehydration conditions. Circ Res. 2018;123(5):e5-e19. https://doi.org/10.1161/circresaha.118.312871
16. Rodriguez S, Lei X, Petersen PS, Tan SY, Little HC, Wong GW. Loss of CTRP1 disrupts glucose and lipid homeostasis. Am J Physiol Endocrinol Metab. 2016;311(4):E678-E97. https://doi.org/10.1152/ajpendo.00087.2016
17. Shen L, Wang S, Ling Y, Liang W. Association of C1q/TNF-related protein-1 (CTRP1) serum levels with coronary artery disease. J Int Med Res. 2019;47(6):2571-9. https://doi.org/10.1177/0300060519847372
2. Salekeen R, Haider AN, Akhter F, Billah MM, Islam ME, Islam KMD. Lipid oxidation in pathophysiology of atherosclerosis: Current understanding and therapeutic strategies. Int J Cardiol Cardiovasc Risk Prev. 2022:200143. https://doi.org/10.1016/j.ijcrp.2022.200143
3. Pan X, Lu T, Wu F, Jin L, Zhang Y, Shi L, et al. Circulating complement-C1q TNF-related protein 1 levels are increased in patients with type 2 diabetes and are associated with insulin sensitivity in Chinese subjects. PloS one. 2014;9(5):e94478. https://doi.org/10.1371/journal.pone.0094478
4. Lasser G, Guchhait P, Ellsworth JL, Sheppard P, Lewis K, Bishop P, et al. C1qTNF–related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen. Blood. 2006;107(2):423-30. https://doi.org/10.1182/blood-2005-04-1425
5. Zhang Y, Liu C, Liu J, Guo R, Yan Z, Liu W, et al. Implications of C1q/TNF-related protein superfamily in patients with coronary artery disease. Sci Rep. 2020;10(1):878. https://doi.org/10.1038/s41598-020-57877-z
6. Wang H, Wang R, Du D, Li F, Li Y. Serum levels of C1q/TNF-related protein-1 (CTRP-1) are closely associated with coronary artery disease. BMC Cardiovasc Disord. 2016;16:1-5. https://doi.org/BMC Cardiovasc. Disord
7. Yuasa D, Ohashi K, Shibata R, Takeshita K, Kikuchi R, Takahashi R, et al. Association of circulating C1q/TNF-related protein 1 levels with coronary artery disease in men. PLoS One. 2014;9(6):e99846. https://doi.org/10.1371/journal.pone.0099846
8. Wang XQ, Liu ZH, Xue L, Lu L, Gao J, Shen Y, et al. C1q/TNF-related protein 1 links macrophage lipid metabolism to inflammation and atherosclerosis. Atherosclerosis. 2016;250:38-45. https://doi.org/10.1016/j.atherosclerosis.2016.04.024
9. Pourghadamyari H, Moghadam ES, Eghbali M, Borji H, Dialamy M, Sadeghi A. Inflammatory indices IL-6, TNF-α, CRP, and hs-CRP in candidates for coronary artery bypass graft surgery. Acta Biochim Iran. 2023;1(3):126-32. https://doi.org/10.18502/abi.v1i3.14548
10. Janowska JD. C1q/TNF-related protein 1, a multifunctional adipokine: an overview of current data. Am J Med Sci. 2020;360(3):222-8. https://doi.org/10.1016/j.amjms.2020.05.036
11. Fadaei R. Adipokines as a link between adipose tissue with inflammation and insulin resistance in cardiometabolic diseases. Acta Biochim Iran. 2023. https://doi.org/10.18502/abi.v1i3.14546
12. Barmoudeh Z, Shahraki MH, Pourghadamyari H, Borj MR, Doustimotlagh AH, Abbaszadeh-Goudarzi K. C1q tumor necrosis factor related proteins (CTRPs) in patients with cardiovascular diseases. Acta Biochim Iran. 2023. https://doi.org/10.18502/abi.v1i1.14060
13. Gu Y, Hu X, Ge P-B, Chen Y, Wu S, Zhang X-W. CTRP1 aggravates cardiac dysfunction post myocardial infarction by modulating TLR4 in macrophages. Front Immunol 2021;12:635267. https://doi.org/10.3389/fimmu.2021.635267
14. Lu L, Zhang RY, Wang XQ, Liu ZH, Shen Y, Ding FH, et al. C1q/TNF-related protein-1: an adipokine marking and promoting atherosclerosis. Eur Heart J 2016;37(22):1762-71. https://doi.org/10.1093/eurheartj/ehv649
15. Han S, Jeong AL, Lee S, Park JS, Buyanravjikh S, Kang W, et al. C1q/TNF-α–related protein 1 (CTRP1) maintains blood pressure under dehydration conditions. Circ Res. 2018;123(5):e5-e19. https://doi.org/10.1161/circresaha.118.312871
16. Rodriguez S, Lei X, Petersen PS, Tan SY, Little HC, Wong GW. Loss of CTRP1 disrupts glucose and lipid homeostasis. Am J Physiol Endocrinol Metab. 2016;311(4):E678-E97. https://doi.org/10.1152/ajpendo.00087.2016
17. Shen L, Wang S, Ling Y, Liang W. Association of C1q/TNF-related protein-1 (CTRP1) serum levels with coronary artery disease. J Int Med Res. 2019;47(6):2571-9. https://doi.org/10.1177/0300060519847372
| Files | ||
| Issue | Vol 3 No 2 (2025) | |
| Section | Original Articles | |
| Keywords | ||
| Coronary artery bypass graft CTRP1 IL-6 TNF-α hs-CRP | ||
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How to Cite
1.
Sadeghi A, Pourghadamyari H, Ramazani-Karim Z, Hajializadeh M, Sajadi Moghadam E, Borji H, Ahmadirad H. Serum CTRP1 Levels in Candidates for Coronary Artery Bypass Graft. ABI. 2025;3(2):120-124.
