Tehran University of Medical Sciences Acta Biochimica Iranica 0001-5261 3 2 2025 06 20 120 124 Hossein Pourghadamyari 1 Applied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, Iran 2 Department of Clinical Biochemistry, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran Zohreh Ramazani-Karim 2 Department of Clinical Biochemistry, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran Mohammad Hajializadeh Medical Student, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Esmaeil Sajadi Moghadam Department of Nursing, School of Nursing and Midwifery, Bam University of Medical Sciences, Bam, Iran Hossein Borji Shafa Hospital, Department of Cardiac Surgery, Kerman University of Medical Sciences, Kerman, Iran Hadis Ahmadirad Pistachio Safety Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Asie Sadeghi Department of Clinical Biochemistry, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran 2025 08 02 2025 08 30 Background: CTRP1 is an adipokine that plays crucial roles in the cardiovascular system, and its dysregulation has been reported in patients with CAD. In this study, our aim was to measure its levels in patients who were candidates for cardiac bypass surgery. Methods: The participants consisted of 30 candidates for coronary artery bypass graft (CABG) surgery and an additional 30 controls. Inflammatory parameters were assessed using enzyme-linked immunosorbent assay (ELISA) kits. Serum CTRP1 concentration was determined using a commercially available ELISA kit. Results: Serum CTRP1 levels significantly increased in the patient group compared to the control group (p-value < 0.0001). Furthermore, CTRP1 levels positively correlated with inflammatory parameters. Conclusion: Elevated levels of CTRP1, along with inflammation in CAD, suggest the involvement of CTRP1 in inflammatory responses. However, this hypothesis remains to be fully elucidated. https://abi.tums.ac.ir/index.php/abi/article/view/146 https://abi.tums.ac.ir/index.php/abi/article/download/146/112