Association of the rs236918 variant of PCSK7 with the prevalence of the metabolic syndrome and its components in population from Ahvaz cohort study: A case-control study in Iran
-
Negar Dinarvand
,
Mojdeh Rahimi
,
Hajieh Shahbazian
,
Maryam Tahmasebi Birgani
,
Bahman Cheraghian
,
Narges Mohammadtaghvaei
Abstract
Objectives: The proprotein convertase subtilisin/kexin type 7 (PCSK7) enzyme is encoded by the PCSK7 gene and is involved in the processing and activation of latent precursor proteins. Previous studies have reported that some PCSK7 variants are associated with markers of body iron stores and lipid profiles, as well as obesity and insulin resistance. The aim of this study was to investigate the association of the rs236918 variant of PCSK7 with metabolic syndrome (MetS) and its related components.
Methods: In this cross-sectional study, 325 participants in the age group of 25 to 86 years were examined. Standard protocols were employed to measure body mass index, blood pressure, fasting blood glucose, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). Individuals with metabolic syndrome (MetS) were identified in accordance with the guidelines set by the National Cholesterol Education Program. Genotype was determined using the PCR-RFLP method.
Results: The findings revealed that there was no association between the rs236918 variant and increased risk of MetS or its components and also plasma lipid profile.
Conclusion: Overall, the findings exhibit no significant association between the PCSK7 rs236918 polymorphism and MetS in this population. Although these results may be due to sample size and power issues, the role of lifestyle factors and other genes in the development of MetS appears to be more important in this population. Therefore, further research is required to validate these results.
1. Saberi, H., N. Mohammadtaghvaei, S. Gulkho, S. Bakhtiyari, M. Mohammadi, P. Hanachi, et al., The ENPP1 K121Q polymorphism is not associated with type 2 diabetes and related metabolic traits in an Iranian population. Molecular and cellular biochemistry, 2011. 350: p. 113-118.
2. Yeh, W.-T. and L.-C. Weng, Epidemiology of metabolic syndrome in Asia. Asia Pacific journal of clinical nutrition, 2008. 17: p. 37-42.
3. Payab, M., S. Hasani-Ranjbar, Y. Merati, A. Esteghamati, M. Qorbani, M. Hematabadi, et al., The prevalence of metabolic syndrome and different obesity phenotype in Iranian male military personnel. American journal of men's health, 2017. 11(2): p. 404-413.
4. Dalvand, S., S.H. Niksima, R. Meshkani, R.G. Gheshlagh, S. Sadegh-Nejadi, W. Kooti, et al., Prevalence of metabolic syndrome among Iranian population: a systematic review and meta-analysis. Iranian journal of public health, 2017. 46(4): p. 456.
5. Grundy, S.M., Metabolic syndrome update. Trends in cardiovascular medicine, 2016. 26(4): p. 364-373.
6. Gorgani-Firuzjaee, S. and R. Meshkani, Resveratrol reduces high glucose-induced de-novo lipogenesis through mTOR mediated induction of autophagy in HepG2 cells. Acta Biochimica Iranica, 2023. 1(1): p. 32-39.
7. Vargas-Alarcón, G., O. Pérez-Méndez, H. González-Pacheco, J. Ramírez-Bello, R. Posadas-Sánchez, G. Escobedo, et al., The rs508487, rs236911, and rs236918 Genetic Variants of the Proprotein Convertase Subtilisin–Kexin Type 7 (PCSK7) Gene Are Associated with Acute Coronary Syndrome and with Plasma Concentrations of HDL-Cholesterol and Triglycerides. Cells, 2021. 10(6): p. 1444.
8. Furuhashi, M., Y. Kataoka, R. Nishikawa, M. Koyama, A. Sakai, Y. Higashiura, et al., Circulating PCSK7 Level is Independently Associated with Obesity, Triglycerides Level and Fatty Liver Index in a General Population without Medication. Journal of Atherosclerosis and Thrombosis, 2022. 29(9): p. 1275-1284.
9. Huang, T., J. Huang, Q. Qi, Y. Li, G.A. Bray, J. Rood, et al., PCSK7 genotype modifies effect of a weight-loss diet on 2-year changes of insulin resistance: the POUNDS LOST trial. Diabetes Care, 2015. 38(3): p. 439-444.
10. Nikooei Sh, A.E., Alipoor B, The emerging role of MALAT1 lncRNA in diabetic nephropathy: based on the review of the literature and bioinformatic analysis. Acta Biochimica Iranica, 2023. 1(3): p. 105-111.
11. Shahbazian, H., S.M. Latifi, M.T. Jalali, H. Shahbazian, R. Amani, A. Nikhoo, et al., Metabolic syndrome and its correlated factors in an urban population in South West of Iran. Journal of Diabetes & Metabolic Disorders, 2013. 12: p. 1-6.
12. Grundy, S.M., J.I. Cleeman, S.R. Daniels, K.A. Donato, R.H. Eckel, B.A. Franklin, et al., Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Circulation, 2005. 112(17): p. 2735-2752.
13. Ghaedrahmat, Z., B. Cheraghian, N. Jaafarzadeh, A. Takdastan, H.B. Shahbazian, and M. Ahmadi, Relationship between urinary heavy metals with metabolic syndrome and its components in population from Hoveyzeh cohort study: A case-control study in Iran. Journal of Trace Elements in Medicine and Biology, 2021. 66: p. 126757.
14. Meshkani, R., M. Zargari, and B. Larijani, The relationship between uric acid and metabolic syndrome in normal glucose tolerance and normal fasting glucose subjects. Acta diabetologica, 2011. 48: p. 79-88.
15. Vykoukal, D. and M.G. Davies, Vascular biology of metabolic syndrome. Journal of vascular surgery, 2011. 54(3): p. 819-831.
16. Chahkandi, S., R. Dabiri, M. Mirmohammadkhani, N. Amiri-Dashatan, and M. Koushki, The effect of silymarin on liver enzymes and serum lipid profiles in Iranian patients with non-alcoholic fatty liver disease: A double-blind randomized controlled trial. Acta Biochimica Iranica, 2023.
17. Emamgholipour, S., Z. Maghbooli, M. Talebpour, S. Gorgani-Firuzjaee, and A. Shirvani, Homeostatic model assessment of β-cell function may be an emerging predictor of bone resorption in metabolically unhealthy obesity. Acta Biochimica Iranica, 2023.
18. Povel, C., J. Boer, E. Reiling, and E. Feskens, Genetic variants and the metabolic syndrome: a systematic review. Obesity Reviews, 2011. 12(11): p. 952-967.
19. Meshkani, R., H. Saberi, N. MohammadTaghvaei, and M.A. Tabatabaiefar, Estrogen receptor alpha gene polymorphisms are associated with type 2 diabetes and fasting glucose in male subjects. Molecular and cellular biochemistry, 2012. 359: p. 225-233.
20. Mazloomi, S. and M.T. Goodarzi, The relationship between chemerin gene polymorphism and the incidence of various diseases. Acta Biochimica Iranica, 2023. 1(2): p. 65-70.
21. Fadaei R, Adipokines as a link between adipose tissue with inflammation and insulin resistance in cardiometabolic diseases. Acta Biochimica Iranica, 2023. 1(3): p. 112-118.
22. Guan, H., J. Zhang, J. Luan, H. Xu, Z. Huang, Q. Yu, et al., Secreted frizzled related proteins in cardiovascular and metabolic diseases. Frontiers in Endocrinology, 2021. 12: p. 712217.
23. Zheng, X., W. Ren, S. Zhang, J. Liu, S. Li, J. Li, et al., Association of type 2 diabetes susceptibility genes (TCF7L2, SLC30A8, PCSK1 and PCSK2) and proinsulin conversion in a Chinese population. Molecular biology reports, 2012. 39: p. 17-23.
24. Saadi, H., N. Nagelkerke, S.G. Carruthers, S. Benedict, S. Abdulkhalek, R. Reed, et al., Association of TCF7L2 polymorphism with diabetes mellitus, metabolic syndrome, and markers of beta cell function and insulin resistance in a population-based sample of Emirati subjects. Diabetes research and clinical practice, 2008. 80(3): p. 392-398.
2. Yeh, W.-T. and L.-C. Weng, Epidemiology of metabolic syndrome in Asia. Asia Pacific journal of clinical nutrition, 2008. 17: p. 37-42.
3. Payab, M., S. Hasani-Ranjbar, Y. Merati, A. Esteghamati, M. Qorbani, M. Hematabadi, et al., The prevalence of metabolic syndrome and different obesity phenotype in Iranian male military personnel. American journal of men's health, 2017. 11(2): p. 404-413.
4. Dalvand, S., S.H. Niksima, R. Meshkani, R.G. Gheshlagh, S. Sadegh-Nejadi, W. Kooti, et al., Prevalence of metabolic syndrome among Iranian population: a systematic review and meta-analysis. Iranian journal of public health, 2017. 46(4): p. 456.
5. Grundy, S.M., Metabolic syndrome update. Trends in cardiovascular medicine, 2016. 26(4): p. 364-373.
6. Gorgani-Firuzjaee, S. and R. Meshkani, Resveratrol reduces high glucose-induced de-novo lipogenesis through mTOR mediated induction of autophagy in HepG2 cells. Acta Biochimica Iranica, 2023. 1(1): p. 32-39.
7. Vargas-Alarcón, G., O. Pérez-Méndez, H. González-Pacheco, J. Ramírez-Bello, R. Posadas-Sánchez, G. Escobedo, et al., The rs508487, rs236911, and rs236918 Genetic Variants of the Proprotein Convertase Subtilisin–Kexin Type 7 (PCSK7) Gene Are Associated with Acute Coronary Syndrome and with Plasma Concentrations of HDL-Cholesterol and Triglycerides. Cells, 2021. 10(6): p. 1444.
8. Furuhashi, M., Y. Kataoka, R. Nishikawa, M. Koyama, A. Sakai, Y. Higashiura, et al., Circulating PCSK7 Level is Independently Associated with Obesity, Triglycerides Level and Fatty Liver Index in a General Population without Medication. Journal of Atherosclerosis and Thrombosis, 2022. 29(9): p. 1275-1284.
9. Huang, T., J. Huang, Q. Qi, Y. Li, G.A. Bray, J. Rood, et al., PCSK7 genotype modifies effect of a weight-loss diet on 2-year changes of insulin resistance: the POUNDS LOST trial. Diabetes Care, 2015. 38(3): p. 439-444.
10. Nikooei Sh, A.E., Alipoor B, The emerging role of MALAT1 lncRNA in diabetic nephropathy: based on the review of the literature and bioinformatic analysis. Acta Biochimica Iranica, 2023. 1(3): p. 105-111.
11. Shahbazian, H., S.M. Latifi, M.T. Jalali, H. Shahbazian, R. Amani, A. Nikhoo, et al., Metabolic syndrome and its correlated factors in an urban population in South West of Iran. Journal of Diabetes & Metabolic Disorders, 2013. 12: p. 1-6.
12. Grundy, S.M., J.I. Cleeman, S.R. Daniels, K.A. Donato, R.H. Eckel, B.A. Franklin, et al., Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Circulation, 2005. 112(17): p. 2735-2752.
13. Ghaedrahmat, Z., B. Cheraghian, N. Jaafarzadeh, A. Takdastan, H.B. Shahbazian, and M. Ahmadi, Relationship between urinary heavy metals with metabolic syndrome and its components in population from Hoveyzeh cohort study: A case-control study in Iran. Journal of Trace Elements in Medicine and Biology, 2021. 66: p. 126757.
14. Meshkani, R., M. Zargari, and B. Larijani, The relationship between uric acid and metabolic syndrome in normal glucose tolerance and normal fasting glucose subjects. Acta diabetologica, 2011. 48: p. 79-88.
15. Vykoukal, D. and M.G. Davies, Vascular biology of metabolic syndrome. Journal of vascular surgery, 2011. 54(3): p. 819-831.
16. Chahkandi, S., R. Dabiri, M. Mirmohammadkhani, N. Amiri-Dashatan, and M. Koushki, The effect of silymarin on liver enzymes and serum lipid profiles in Iranian patients with non-alcoholic fatty liver disease: A double-blind randomized controlled trial. Acta Biochimica Iranica, 2023.
17. Emamgholipour, S., Z. Maghbooli, M. Talebpour, S. Gorgani-Firuzjaee, and A. Shirvani, Homeostatic model assessment of β-cell function may be an emerging predictor of bone resorption in metabolically unhealthy obesity. Acta Biochimica Iranica, 2023.
18. Povel, C., J. Boer, E. Reiling, and E. Feskens, Genetic variants and the metabolic syndrome: a systematic review. Obesity Reviews, 2011. 12(11): p. 952-967.
19. Meshkani, R., H. Saberi, N. MohammadTaghvaei, and M.A. Tabatabaiefar, Estrogen receptor alpha gene polymorphisms are associated with type 2 diabetes and fasting glucose in male subjects. Molecular and cellular biochemistry, 2012. 359: p. 225-233.
20. Mazloomi, S. and M.T. Goodarzi, The relationship between chemerin gene polymorphism and the incidence of various diseases. Acta Biochimica Iranica, 2023. 1(2): p. 65-70.
21. Fadaei R, Adipokines as a link between adipose tissue with inflammation and insulin resistance in cardiometabolic diseases. Acta Biochimica Iranica, 2023. 1(3): p. 112-118.
22. Guan, H., J. Zhang, J. Luan, H. Xu, Z. Huang, Q. Yu, et al., Secreted frizzled related proteins in cardiovascular and metabolic diseases. Frontiers in Endocrinology, 2021. 12: p. 712217.
23. Zheng, X., W. Ren, S. Zhang, J. Liu, S. Li, J. Li, et al., Association of type 2 diabetes susceptibility genes (TCF7L2, SLC30A8, PCSK1 and PCSK2) and proinsulin conversion in a Chinese population. Molecular biology reports, 2012. 39: p. 17-23.
24. Saadi, H., N. Nagelkerke, S.G. Carruthers, S. Benedict, S. Abdulkhalek, R. Reed, et al., Association of TCF7L2 polymorphism with diabetes mellitus, metabolic syndrome, and markers of beta cell function and insulin resistance in a population-based sample of Emirati subjects. Diabetes research and clinical practice, 2008. 80(3): p. 392-398.
| Files | ||
| Issue | Vol 1 No 4 (2023) | |
| Section | Original Articles | |
| DOI | https://doi.org/10.18502/abi.v1i4.14722 | |
| Keywords | ||
| Metabolic Syndrome PCSK7 rs236918 RFLP | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Dinarvand N, Rahimi M, Shahbazian H, Tahmasebi Birgani M, Cheraghian B, Mohammadtaghvaei N. Association of the rs236918 variant of PCSK7 with the prevalence of the metabolic syndrome and its components in population from Ahvaz cohort study: A case-control study in Iran. ABI. 2023;1(4):196-200.
