Genistein in combination with Chlorogenic acid ameliorates insulin resistance and oxidative stress in skeletal muscle of high-fat diet fed mice
Abstract
Objectives: Increasing evidence has demonstrated that oxidative stress plays a significant role in the pathogenesis of muscle insulin resistance. The beneficial impacts of genistein (GEN) and chlorogenic acid (CGA) on insulin resistance have already been revealed. However, their combined effects on skeletal muscle oxidative stress and insulin resistance have not been completely understood. The aim of the present study was to determine the effect of GEN in combination with CGA on skeletal muscle insulin resistance in high-fat diet (HFD) fed C57BL/6 mice.
Methods: C57BL/6 male mice were fed an HFD for 15 weeks. The mice were then divided into five groups: standard chow diet (SCD), HFD, HFD + GEN, HFD + CGA, and HFD + GEN + CGA for 10 weeks.
Results: The findings indicated that single treatment with GEN or CGA, and with a stronger effect of GEN+CGA combined treatment, decreased body weight gain and improved glucose intolerance. Moreover, following treatment with GEN and CGA alone or in combination with further effect, the level of plasma and muscle triglyceride (TG) were reduced. Furthermore, the combination therapy of GEN and CGA with greater efficacy than the single treatments, could decrease several oxidative stress markers in the skeletal muscle. Treatment with GEN and CGA alone or in combination could increase the expression of NF-E2–related factor 2 (Nrf2), heme oxygenase-1 (HO-1), and NAD(P): Quinone Oxidoreductase 1 (NQO1).
Conclusion: The data of this study suggest that the combination of GEN and CGA might ameliorate insulin resistance and reduce oxidative stress in the skeletal muscle of mice fed HFD.
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6. Somayeh Chahkandi , R.D., Majid Mirmohammadkhani, Nasrin Amiri-Dashatan, Mehdi Koushki, The Effect of Silymarin on Liver Enzymes and Serum Lipid Profiles in Iranian Patients with Non-alcoholic fatty liver disease: A Double-blind Randomized Controlled Trial. Acta Biochimica Iranica, 2023. 1(2): p. 83-89.
7. Henriksen, E.J., M.K. Diamond-Stanic, and E.M. Marchionne, Oxidative stress and the etiology of insulin resistance and type 2 diabetes. Free Radical Biology and Medicine, 2011. 51(5): p. 993-999.
8. Sarabandi, S., H. Effatpanah, N. Sereshki, S. Samavarchi Tehrani, and H. Moradi-Sardareh, 50-bp insertion/deletion polymorphism of the superoxide dismutase-1 is associated with bladder cancer risk in an Iranian population. Nucleosides, Nucleotides & Nucleic Acids, 2022. 41(2): p. 154-165.
9. Sifuentes-Franco, S., F.P. Pacheco-Moisés, A.D. Rodríguez-Carrizalez, and A.G. Miranda-Díaz, The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy. J Diabetes Res, 2017. 2017: p. 1673081.
10. Seyyedebrahimi, S., H. Khodabandehloo, E. Nasli Esfahani, and R. Meshkani, The effects of resveratrol on markers of oxidative stress in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial. Acta Diabetol, 2018. 55(4): p. 341-353.
11. Pérez-Torres, I., V. Castrejón-Téllez, M.E. Soto, M.E. Rubio-Ruiz, L. Manzano-Pech, and V. Guarner-Lans, Oxidative Stress, Plant Natural Antioxidants, and Obesity. Int J Mol Sci, 2021. 22(4).
12. Tehrani, S.S., G. Goodarzi, G. Panahi, F. Zamani-Garmsiri, and R. Meshkani, The combination of metformin with morin alleviates hepatic steatosis via modulating hepatic lipid metabolism, hepatic inflammation, brown adipose tissue thermogenesis, and white adipose tissue browning in high-fat diet-fed mice. Life Sciences, 2023. 323: p. 121706.
13. Goodarzi, G., S.S. Tehrani, G. Panahi, A. Bahramzadeh, and R. Meshkani, Combination therapy of metformin and p-coumaric acid mitigates metabolic dysfunction associated with obesity and nonalcoholic fatty liver disease in high-fat diet obese C57BL/6 mice. The Journal of Nutritional Biochemistry, 2023. 118: p. 109369.
14. Hossein Ghahremani, A.B., Kosar Bolandnazar , Solaleh Emamgholipor, Hossein Hosseini , Reza Meshkani Resveratrol as a Potential Protective Compound Against Metabolic Inflammation. Acta Biochimica Iranica, 2023. 1(2): p. 50-64.
15. Reyhaneh Babaei Khorzoughi , R.M., Beneficial Effect of Metformin, Quercetin, and Resveratrol Combination on High Glucose-Induced lipogenesis in HepG2 Cells. Acta Biochimica Iranica, 2023. 1(2): p. 96-104.
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18. Nagaraju, G.P., S.F. Zafar, and B.F. El-Rayes, Pleiotropic effects of genistein in metabolic, inflammatory, and malignant diseases. Nutr Rev, 2013. 71(8): p. 562-72.
19. Aliabadi, M., F. Zamani-Garmsiri, G. Panahi, S.S. Tehrani, and R. Meshkani, Metformin in combination with genistein ameliorates skeletal muscle inflammation in high-fat diet fed c57BL/6 mice. Cytokine, 2021. 146: p. 155638.
20. Lee, Y.M., J.S. Choi, M.H. Kim, M.H. Jung, Y.S. Lee, and J. Song, Effects of dietary genistein on hepatic lipid metabolism and mitochondrial function in mice fed high-fat diets. Nutrition, 2006. 22(9): p. 956-64.
21. Yang, J.Y., S.J. Lee, H.W. Park, and Y.S. Cha, Effect of genistein with carnitine administration on lipid parameters and obesity in C57Bl/6J mice fed a high-fat diet. J Med Food, 2006. 9(4): p. 459-67.
22. Zamani‐Garmsiri, F., S. Emamgholipour, S. Rahmani Fard, G. Ghasempour, R. Jahangard Ahvazi, and R. Meshkani, Polyphenols: potential anti‐inflammatory agents for treatment of metabolic disorders. Phytotherapy Research, 2022. 36(1): p. 415-432.
23. Kim, M.J. and Y. Lim, Protective effect of short-term genistein supplementation on the early stage in diabetes-induced renal damage. Mediators Inflamm, 2013. 2013: p. 510212.
24. Lu, H., Z. Tian, Y. Cui, Z. Liu, and X. Ma, Chlorogenic acid: A comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions. Compr Rev Food Sci Food Saf, 2020. 19(6): p. 3130-3158.
25. Liang, N. and D.D. Kitts, Role of Chlorogenic Acids in Controlling Oxidative and Inflammatory Stress Conditions. Nutrients, 2015. 8(1).
26. Santana-Gálvez, J., L. Cisneros-Zevallos, and D.A. Jacobo-Velázquez, Chlorogenic Acid: Recent Advances on Its Dual Role as a Food Additive and a Nutraceutical against Metabolic Syndrome. Molecules, 2017. 22(3).
27. Ye, H.Y., Z.Y. Li, Y. Zheng, Y. Chen, Z.H. Zhou, and J. Jin, The attenuation of chlorogenic acid on oxidative stress for renal injury in streptozotocin-induced diabetic nephropathy rats. Arch Pharm Res, 2016. 39(7): p. 989-97.
28. Zamani-Garmsiri, F., G. Ghasempour, M. Aliabadi, S.M.R. Hashemnia, S. Emamgholipour, and R. Meshkani, Combination of metformin and chlorogenic acid attenuates hepatic steatosis and inflammation in high-fat diet fed mice. IUBMB Life, 2021. 73(1): p. 252-263.
29. Zamani-Garmsiri, F., S.M.R. Hashemnia, M. Shabani, M. Bagherieh, S. Emamgholipour, and R. Meshkani, Combination of metformin and genistein alleviates non-alcoholic fatty liver disease in high-fat diet-fed mice. J Nutr Biochem, 2021. 87: p. 108505.
30. Folch, J., M. Lees, and G.H. Sloane Stanley, A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem, 1957. 226(1): p. 497-509.
31. Benzie, I.F. and J.J. Strain, The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem, 1996. 239(1): p. 70-6.
32. Shiri, H., A. Karimpour, M. Sattari, S. Hemmati, S. Seyyedebrahimi, and G. Panahi, Evaluation of Antioxidant Potential and Free Radical Scavenging Activity of Methanol Extract from Scrophularia striata. Acta Biochimica Iranica, 2023. 1(2): p. 71-77.
33. Sedlak, J. and R.H. Lindsay, Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem, 1968. 25(1): p. 192-205.
34. Aguilar Diaz De Leon, J. and C.R. Borges, Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay. J Vis Exp, 2020(159).
35. Reznick, A.Z. and L. Packer, Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Methods Enzymol, 1994. 233: p. 357-63.
36. Roya Jahangard , S.S.S.E., Akram Vatannejad, Reza Meshkani Autophagy protects peripheral blood mononuclear cells from high glucose-induced inflammation and apoptosis. Acta Biochimica Iranica, 2023. 1(1): p. 40-49.
37. Yaser Mohassel , S.A., Shayan Mostafae , Mohammad Taghi Goodarzi Assessing the Possible Association between Polymorphism of C677T MTHFR with Preeclampsia Risk: A Systematic Review and Bayesian Hierarchical Meta-Analysis. Acta Biochimica Iranica, 2023. 1(1): p. 3-11.
38. Di Meo, S., S. Iossa, and P. Venditti, Skeletal muscle insulin resistance: role of mitochondria and other ROS sources. J Endocrinol, 2017. 233(1): p. R15-r42.
39. Eddouks, M., D. Chattopadhyay, V. De Feo, and W.C. Cho, Medicinal plants in the prevention and treatment of chronic diseases. Evid Based Complement Alternat Med, 2012. 2012: p. 458274.
40. Tabatabaei-Malazy, O., B. Larijani, and M. Abdollahi, Targeting metabolic disorders by natural products. J Diabetes Metab Disord, 2015. 14: p. 57.
41. Cho, A.S., S.M. Jeon, M.J. Kim, J. Yeo, K.I. Seo, M.S. Choi, et al., Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice. Food Chem Toxicol, 2010. 48(3): p. 937-43.
42. Ji, G., Y. Zhang, Q. Yang, S. Cheng, J. Hao, X. Zhao, et al., Genistein suppresses LPS-induced inflammatory response through inhibiting NF-κB following AMP kinase activation in RAW 264.7 macrophages. PLoS One, 2012. 7(12): p. e53101.
43. Zhang, L.T., C.Q. Chang, Y. Liu, and Z.M. Chen, Effect of chlorogenic acid on disordered glucose and lipid metabolism in db/db mice and its mechanism. Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2011. 33(3): p. 281-6.
44. Wang, C.Y. and J.K. Liao, A mouse model of diet-induced obesity and insulin resistance. Methods Mol Biol, 2012. 821: p. 421-33.
45. Ae Park, S., M.S. Choi, S.Y. Cho, J.S. Seo, U.J. Jung, M.J. Kim, et al., Genistein and daidzein modulate hepatic glucose and lipid regulating enzyme activities in C57BL/KsJ-db/db mice. Life Sci, 2006. 79(12): p. 1207-13.
46. Ong, K.W., A. Hsu, and B.K. Tan, Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation. Biochem Pharmacol, 2013. 85(9): p. 1341-51.
47. Shen, S., Q. Liao, T. Zhang, R. Pan, and L. Lin, Myricanol modulates skeletal muscle-adipose tissue crosstalk to alleviate high-fat diet-induced obesity and insulin resistance. Br J Pharmacol, 2019. 176(20): p. 3983-4001.
48. Mubarak, A., J.M. Hodgson, M.J. Considine, K.D. Croft, and V.B. Matthews, Supplementation of a high-fat diet with chlorogenic acid is associated with insulin resistance and hepatic lipid accumulation in mice. J Agric Food Chem, 2013. 61(18): p. 4371-8.
49. Zheng, G., Y. Qiu, Q.F. Zhang, and D. Li, Chlorogenic acid and caffeine in combination inhibit fat accumulation by regulating hepatic lipid metabolism-related enzymes in mice. Br J Nutr, 2014. 112(6): p. 1034-40.
50. Boucher, J., A. Kleinridders, and C.R. Kahn, Insulin receptor signaling in normal and insulin-resistant states. Cold Spring Harb Perspect Biol, 2014. 6(1).
51. Jheng, H.F., P.J. Tsai, S.M. Guo, L.H. Kuo, C.S. Chang, I.J. Su, et al., Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle. Mol Cell Biol, 2012. 32(2): p. 309-19.
52. Hosseini, H., M. Teimouri, M. Shabani, M. Koushki, R. Babaei Khorzoughi, F. Namvarjah, et al., Resveratrol alleviates non-alcoholic fatty liver disease through epigenetic modification of the Nrf2 signaling pathway. Int J Biochem Cell Biol, 2020. 119: p. 105667.
53. Li, S., N. Eguchi, H. Lau, and H. Ichii, The Role of the Nrf2 Signaling in Obesity and Insulin Resistance. Int J Mol Sci, 2020. 21(18).
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2. Yaribeygi, H., T. Sathyapalan, S.L. Atkin, and A. Sahebkar, Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus. Oxid Med Cell Longev, 2020. 2020: p. 8609213.
3. Balakrishnan, R. and D.C. Thurmond, Mechanisms by Which Skeletal Muscle Myokines Ameliorate Insulin Resistance. Int J Mol Sci, 2022. 23(9).
4. Bahramzadeh, A., K. Bolandnazar, and R. Meshkani, Resveratrol as a potential protective compound against skeletal muscle insulin resistance. Heliyon, 2023.
5. Darenskaya, M.A., L.I. Kolesnikova, and S.I. Kolesnikov, Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction. Bull Exp Biol Med, 2021. 171(2): p. 179-189.
6. Somayeh Chahkandi , R.D., Majid Mirmohammadkhani, Nasrin Amiri-Dashatan, Mehdi Koushki, The Effect of Silymarin on Liver Enzymes and Serum Lipid Profiles in Iranian Patients with Non-alcoholic fatty liver disease: A Double-blind Randomized Controlled Trial. Acta Biochimica Iranica, 2023. 1(2): p. 83-89.
7. Henriksen, E.J., M.K. Diamond-Stanic, and E.M. Marchionne, Oxidative stress and the etiology of insulin resistance and type 2 diabetes. Free Radical Biology and Medicine, 2011. 51(5): p. 993-999.
8. Sarabandi, S., H. Effatpanah, N. Sereshki, S. Samavarchi Tehrani, and H. Moradi-Sardareh, 50-bp insertion/deletion polymorphism of the superoxide dismutase-1 is associated with bladder cancer risk in an Iranian population. Nucleosides, Nucleotides & Nucleic Acids, 2022. 41(2): p. 154-165.
9. Sifuentes-Franco, S., F.P. Pacheco-Moisés, A.D. Rodríguez-Carrizalez, and A.G. Miranda-Díaz, The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy. J Diabetes Res, 2017. 2017: p. 1673081.
10. Seyyedebrahimi, S., H. Khodabandehloo, E. Nasli Esfahani, and R. Meshkani, The effects of resveratrol on markers of oxidative stress in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial. Acta Diabetol, 2018. 55(4): p. 341-353.
11. Pérez-Torres, I., V. Castrejón-Téllez, M.E. Soto, M.E. Rubio-Ruiz, L. Manzano-Pech, and V. Guarner-Lans, Oxidative Stress, Plant Natural Antioxidants, and Obesity. Int J Mol Sci, 2021. 22(4).
12. Tehrani, S.S., G. Goodarzi, G. Panahi, F. Zamani-Garmsiri, and R. Meshkani, The combination of metformin with morin alleviates hepatic steatosis via modulating hepatic lipid metabolism, hepatic inflammation, brown adipose tissue thermogenesis, and white adipose tissue browning in high-fat diet-fed mice. Life Sciences, 2023. 323: p. 121706.
13. Goodarzi, G., S.S. Tehrani, G. Panahi, A. Bahramzadeh, and R. Meshkani, Combination therapy of metformin and p-coumaric acid mitigates metabolic dysfunction associated with obesity and nonalcoholic fatty liver disease in high-fat diet obese C57BL/6 mice. The Journal of Nutritional Biochemistry, 2023. 118: p. 109369.
14. Hossein Ghahremani, A.B., Kosar Bolandnazar , Solaleh Emamgholipor, Hossein Hosseini , Reza Meshkani Resveratrol as a Potential Protective Compound Against Metabolic Inflammation. Acta Biochimica Iranica, 2023. 1(2): p. 50-64.
15. Reyhaneh Babaei Khorzoughi , R.M., Beneficial Effect of Metformin, Quercetin, and Resveratrol Combination on High Glucose-Induced lipogenesis in HepG2 Cells. Acta Biochimica Iranica, 2023. 1(2): p. 96-104.
16. Incir, S., I.M. Bolayirli, O. Inan, M.S. Aydın, I.A. Bilgin, I. Sayan, et al., The effects of genistein supplementation on fructose induced insulin resistance, oxidative stress and inflammation. Life Sci, 2016. 158: p. 57-62.
17. Behloul, N. and G. Wu, Genistein: a promising therapeutic agent for obesity and diabetes treatment. Eur J Pharmacol, 2013. 698(1-3): p. 31-8.
18. Nagaraju, G.P., S.F. Zafar, and B.F. El-Rayes, Pleiotropic effects of genistein in metabolic, inflammatory, and malignant diseases. Nutr Rev, 2013. 71(8): p. 562-72.
19. Aliabadi, M., F. Zamani-Garmsiri, G. Panahi, S.S. Tehrani, and R. Meshkani, Metformin in combination with genistein ameliorates skeletal muscle inflammation in high-fat diet fed c57BL/6 mice. Cytokine, 2021. 146: p. 155638.
20. Lee, Y.M., J.S. Choi, M.H. Kim, M.H. Jung, Y.S. Lee, and J. Song, Effects of dietary genistein on hepatic lipid metabolism and mitochondrial function in mice fed high-fat diets. Nutrition, 2006. 22(9): p. 956-64.
21. Yang, J.Y., S.J. Lee, H.W. Park, and Y.S. Cha, Effect of genistein with carnitine administration on lipid parameters and obesity in C57Bl/6J mice fed a high-fat diet. J Med Food, 2006. 9(4): p. 459-67.
22. Zamani‐Garmsiri, F., S. Emamgholipour, S. Rahmani Fard, G. Ghasempour, R. Jahangard Ahvazi, and R. Meshkani, Polyphenols: potential anti‐inflammatory agents for treatment of metabolic disorders. Phytotherapy Research, 2022. 36(1): p. 415-432.
23. Kim, M.J. and Y. Lim, Protective effect of short-term genistein supplementation on the early stage in diabetes-induced renal damage. Mediators Inflamm, 2013. 2013: p. 510212.
24. Lu, H., Z. Tian, Y. Cui, Z. Liu, and X. Ma, Chlorogenic acid: A comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions. Compr Rev Food Sci Food Saf, 2020. 19(6): p. 3130-3158.
25. Liang, N. and D.D. Kitts, Role of Chlorogenic Acids in Controlling Oxidative and Inflammatory Stress Conditions. Nutrients, 2015. 8(1).
26. Santana-Gálvez, J., L. Cisneros-Zevallos, and D.A. Jacobo-Velázquez, Chlorogenic Acid: Recent Advances on Its Dual Role as a Food Additive and a Nutraceutical against Metabolic Syndrome. Molecules, 2017. 22(3).
27. Ye, H.Y., Z.Y. Li, Y. Zheng, Y. Chen, Z.H. Zhou, and J. Jin, The attenuation of chlorogenic acid on oxidative stress for renal injury in streptozotocin-induced diabetic nephropathy rats. Arch Pharm Res, 2016. 39(7): p. 989-97.
28. Zamani-Garmsiri, F., G. Ghasempour, M. Aliabadi, S.M.R. Hashemnia, S. Emamgholipour, and R. Meshkani, Combination of metformin and chlorogenic acid attenuates hepatic steatosis and inflammation in high-fat diet fed mice. IUBMB Life, 2021. 73(1): p. 252-263.
29. Zamani-Garmsiri, F., S.M.R. Hashemnia, M. Shabani, M. Bagherieh, S. Emamgholipour, and R. Meshkani, Combination of metformin and genistein alleviates non-alcoholic fatty liver disease in high-fat diet-fed mice. J Nutr Biochem, 2021. 87: p. 108505.
30. Folch, J., M. Lees, and G.H. Sloane Stanley, A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem, 1957. 226(1): p. 497-509.
31. Benzie, I.F. and J.J. Strain, The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem, 1996. 239(1): p. 70-6.
32. Shiri, H., A. Karimpour, M. Sattari, S. Hemmati, S. Seyyedebrahimi, and G. Panahi, Evaluation of Antioxidant Potential and Free Radical Scavenging Activity of Methanol Extract from Scrophularia striata. Acta Biochimica Iranica, 2023. 1(2): p. 71-77.
33. Sedlak, J. and R.H. Lindsay, Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem, 1968. 25(1): p. 192-205.
34. Aguilar Diaz De Leon, J. and C.R. Borges, Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay. J Vis Exp, 2020(159).
35. Reznick, A.Z. and L. Packer, Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Methods Enzymol, 1994. 233: p. 357-63.
36. Roya Jahangard , S.S.S.E., Akram Vatannejad, Reza Meshkani Autophagy protects peripheral blood mononuclear cells from high glucose-induced inflammation and apoptosis. Acta Biochimica Iranica, 2023. 1(1): p. 40-49.
37. Yaser Mohassel , S.A., Shayan Mostafae , Mohammad Taghi Goodarzi Assessing the Possible Association between Polymorphism of C677T MTHFR with Preeclampsia Risk: A Systematic Review and Bayesian Hierarchical Meta-Analysis. Acta Biochimica Iranica, 2023. 1(1): p. 3-11.
38. Di Meo, S., S. Iossa, and P. Venditti, Skeletal muscle insulin resistance: role of mitochondria and other ROS sources. J Endocrinol, 2017. 233(1): p. R15-r42.
39. Eddouks, M., D. Chattopadhyay, V. De Feo, and W.C. Cho, Medicinal plants in the prevention and treatment of chronic diseases. Evid Based Complement Alternat Med, 2012. 2012: p. 458274.
40. Tabatabaei-Malazy, O., B. Larijani, and M. Abdollahi, Targeting metabolic disorders by natural products. J Diabetes Metab Disord, 2015. 14: p. 57.
41. Cho, A.S., S.M. Jeon, M.J. Kim, J. Yeo, K.I. Seo, M.S. Choi, et al., Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice. Food Chem Toxicol, 2010. 48(3): p. 937-43.
42. Ji, G., Y. Zhang, Q. Yang, S. Cheng, J. Hao, X. Zhao, et al., Genistein suppresses LPS-induced inflammatory response through inhibiting NF-κB following AMP kinase activation in RAW 264.7 macrophages. PLoS One, 2012. 7(12): p. e53101.
43. Zhang, L.T., C.Q. Chang, Y. Liu, and Z.M. Chen, Effect of chlorogenic acid on disordered glucose and lipid metabolism in db/db mice and its mechanism. Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2011. 33(3): p. 281-6.
44. Wang, C.Y. and J.K. Liao, A mouse model of diet-induced obesity and insulin resistance. Methods Mol Biol, 2012. 821: p. 421-33.
45. Ae Park, S., M.S. Choi, S.Y. Cho, J.S. Seo, U.J. Jung, M.J. Kim, et al., Genistein and daidzein modulate hepatic glucose and lipid regulating enzyme activities in C57BL/KsJ-db/db mice. Life Sci, 2006. 79(12): p. 1207-13.
46. Ong, K.W., A. Hsu, and B.K. Tan, Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation. Biochem Pharmacol, 2013. 85(9): p. 1341-51.
47. Shen, S., Q. Liao, T. Zhang, R. Pan, and L. Lin, Myricanol modulates skeletal muscle-adipose tissue crosstalk to alleviate high-fat diet-induced obesity and insulin resistance. Br J Pharmacol, 2019. 176(20): p. 3983-4001.
48. Mubarak, A., J.M. Hodgson, M.J. Considine, K.D. Croft, and V.B. Matthews, Supplementation of a high-fat diet with chlorogenic acid is associated with insulin resistance and hepatic lipid accumulation in mice. J Agric Food Chem, 2013. 61(18): p. 4371-8.
49. Zheng, G., Y. Qiu, Q.F. Zhang, and D. Li, Chlorogenic acid and caffeine in combination inhibit fat accumulation by regulating hepatic lipid metabolism-related enzymes in mice. Br J Nutr, 2014. 112(6): p. 1034-40.
50. Boucher, J., A. Kleinridders, and C.R. Kahn, Insulin receptor signaling in normal and insulin-resistant states. Cold Spring Harb Perspect Biol, 2014. 6(1).
51. Jheng, H.F., P.J. Tsai, S.M. Guo, L.H. Kuo, C.S. Chang, I.J. Su, et al., Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle. Mol Cell Biol, 2012. 32(2): p. 309-19.
52. Hosseini, H., M. Teimouri, M. Shabani, M. Koushki, R. Babaei Khorzoughi, F. Namvarjah, et al., Resveratrol alleviates non-alcoholic fatty liver disease through epigenetic modification of the Nrf2 signaling pathway. Int J Biochem Cell Biol, 2020. 119: p. 105667.
53. Li, S., N. Eguchi, H. Lau, and H. Ichii, The Role of the Nrf2 Signaling in Obesity and Insulin Resistance. Int J Mol Sci, 2020. 21(18).
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| Files | ||
| Issue | Vol 1 No 3 (2023) | |
| Section | Original Articles | |
| DOI | https://doi.org/10.18502/abi.v1i3.14551 | |
| Keywords | ||
| Genistein Chlorogenic Acid Oxidative Stress Insulin resistance Skeletal Muscle Nrf2 | ||
| Rights and permissions | |
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Goodarzi G, Yadollahi M, Samavarchi Tehrani S, Meshkani R. Genistein in combination with Chlorogenic acid ameliorates insulin resistance and oxidative stress in skeletal muscle of high-fat diet fed mice. ABI. 2023;1(3):145-153.
