The Relationship Between Chemerin Gene Polymorphism and the Incidence of Various Diseases
Abstract
Adipose tissue is recognized as an endocrine organ that influences the health status of other tissues by releasing various adipokines. Chemerin is one such adipokine, and its serum level exhibits a positive correlation with the amount of fat tissue and obesity. Certain genetic polymorphisms of chemerin, namely rs17173608, rs1799983, rs693, rs4721, and rs3735167, are known to be associated with diseases such as diabetes, gestational diabetes mellitus (GDM), obesity, insulin resistance (IR), cardiovascular diseases, metabolic syndrome (MetS), end stage renal disease (ESRD), polycystic ovary syndrome (PCOS), and rheumatoid arthritis (RA). Existing data suggest that chemerin is also associated with inflammatory diseases. This review focuses on the association between the genetic variants or polymorphisms of chemerin and some pathological states.
1. Bozaoglu, K., J.E. Curran, C.J. Stocker, M.S. Zaibi, D. Segal, N. Konstantopoulos, et al., Chemerin, a Novel Adipokine in the Regulation of Angiogenesis. The Journal of Clinical Endocrinology & Metabolism, 2010. 95(5): p. 2476-2485.
2. Adeli, K., A Journey Forward: Acta Biochimica Iranica’s Rebirth and its Impact on the Evolution of Clinical Laboratory Sciences. Acta Biochimica Iranica, 2023. 1(1): p. 1-2.
3. Wittamer, V., F. Grégoire, P. Robberecht, G. Vassart, D. Communi, and M. Parmentier, The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency. Journal of Biological Chemistry, 2004. 279(11): p. 9956-9962.
4. Ben Dhaou, C., K. Mandi, M. Frye, A. Acheampong, A. Radi, B. De Becker, et al., Chemerin regulates normal angiogenesis and hypoxia-driven neovascularization. Angiogenesis, 2022. 25(2): p. 159-179.
5. Perumalsamy, S., N. Ain Aqilah Mohd Zin, R. Teguh Widodo, W. Azman Wan Ahmad, R.D. Vethakkan, and H. Zaman Huri, Chemokine like receptor-1 (CMKLR-1) receptor: a potential therapeutic target in management of chemerin induced type 2 diabetes mellitus and cancer. Current pharmaceutical design, 2017. 23(25): p. 3689-3698.
6. Nima Taghizadeh , S.M., Vahid Saeedi, Ladan Haghighi, Mona Nourbakhsh, Mitra Nourbakhsh, Maryam Razzaghy Azar, Association between Steroid Hormones and Insulin Resistance in Patients with Polycystic Ovary Syndrome. Acta Biochimica Iranica, 2023. 1(1): p. 26-31.
7. Dubois-Vedrenne, I., D. Al Delbany, O. De Henau, V. Robert, M. Vernimmen, F. Langa, et al., The antitumoral effects of chemerin are independent from leukocyte recruitment and mediated by inhibition of neoangiogenesis. Oncotarget, 2021. 12(19): p. 1903-1919.
8. Shin, W.J., B.A. Zabel, and R.K. Pachynski, Mechanisms and functions of chemerin in cancer: potential roles in therapeutic intervention. Frontiers in immunology, 2018. 9: p. 2772.
9. Nagpal, S., S. Patel, H. Jacobe, D. DiSepio, C. Ghosn, M. Malhotra, et al., Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene in skin. Journal of Investigative Dermatology, 1997. 109(1): p. 91-95.
10. Ernst, M.C. and C.J. Sinal, Chemerin: at the crossroads of inflammation and obesity. Trends in Endocrinology & Metabolism, 2010. 21(11): p. 660-667.
11. Chang, S.S., D. Eisenberg, L. Zhao, C. Adams, R. Leib, J. Morser, et al., Chemerin activation in human obesity. Obesity, 2016. 24(7): p. 1522-1529.
12. Mlyczyńska, E., M. Kieżun, P. Kurowska, M. Dawid, K. Pich, N. Respekta, et al., New Aspects of Corpus Luteum Regulation in Physiological and Pathological Conditions: Involvement of Adipokines and Neuropeptides. Cells, 2022. 11(6): p. 957.
13. Eichelmann, F., M.B. Schulze, C. Wittenbecher, J. Menzel, C. Weikert, R. di Giuseppe, et al., Association of chemerin plasma concentration with risk of colorectal cancer. JAMA network open, 2019. 2(3): p. e190896-e190896.
14. Helfer, G. and Q.-F. Wu, Chemerin: a multifaceted adipokine involved in metabolic disorders. Journal of Endocrinology, 2018. 238(2): p. R79-R94.
15. Zhao, K., W. Ding, Y. Zhang, K. Ma, D. Wang, C. Hu, et al., Variants in the RARRES2 gene are associated with serum chemerin and increase the risk of diabetic kidney disease in type 2 diabetes. International Journal of Biological Macromolecules, 2020. 165: p. 1574-1580.
16. Léniz, A., M. González, I. Besné, H. Carr-Ugarte, I. Gómez- García, and M.P. Portillo, Role of chemerin in the control of glucose homeostasis. Molecular and Cellular Endocrinology, 2022. 541: p. 111504.
17. Er, L.K., L.A. Hsu, J.J. Juang, F.T. Chiang, M.S. Teng, I.S. Tzeng, et al., Circulating Chemerin Levels, but not the RARRES2 Polymorphisms, Predict the Long-Term Outcome of Angiographically Confirmed Coronary Artery Disease. Int J Mol Sci, 2019. 20(5).
18. Zheng, Q., J. Jiang, Y. Huo, and D. Chen, Genetic predisposition to type 2 diabetes is associated with severity of coronary artery disease in patients with acute coronary syndromes. Cardiovasc Diabetol, 2019. 18(1): p. 131.
19. Dahpy, M.A., M.K. Khairallah, N.M.A. Azoz, and G.M. Ezzat, The associations among RARRES2 rs17173608 gene polymorphism, serum chemerin, and non-traditional lipid profile in patients with metabolic syndrome. Egyptian Journal of Medical Human Genetics, 2020. 21(1): p. 1-13.
20. Olt, S., O. Öznas, H. Bağış, and E.T. Turanlı, Chemerin rs17173608 Gene Polymorphism is not Associated with Type 2 Diabetes Mellitus: a Cross-sectional Study. Folia medica, 2019. 61(1): p. 69-75.
21. Abdelhamid, A.M. and M.A. Zaafan. Association of chemerin rs17173608 and vaspin rs2236242 polymorphisms with type two diabetes mellitus and its impact on their corresponding serum levels in Egyptian population. 2019. ideas.
22. Perumalsamy, S., W.A. Wan Ahmad, and H. Zaman Huri, Single Nucleotide Polymorphism rs17173608 in the Chemerin Encoding Gene: Is It a Predictor of Insulin Resistance and Severity of Coronary Artery Disease in Non-Obese Type 2 Diabetes? Healthcare, 2021. 9(6): p. 623.
23. Wang, H., N. Li, T. Chivese, M. Werfalli, H. Sun, L. Yuen, et al., IDF Diabetes Atlas: Estimation of Global and Regional Gestational Diabetes Mellitus Prevalence for 2021 by International Association of Diabetes in Pregnancy Study Group’s Criteria. Diabetes Research and Clinical Practice, 2022. 183: p. 109050.
24. Hamzeh Saberi , G.T., Reza Meshkani The ENPP1 K121Q polymorphism is associated with obesity-related parameters in Iranian normoglycemic male subjects. Acta Biochimica Iranica, 2023. 1(1): p. 20-25.
25. Hare, K., L. Bonde, J. Svare, H. Randeva, M. Asmar, S. Larsen, et al., Decreased plasma chemerin levels in women with gestational diabetes mellitus. Diabetic Medicine, 2014. 31(8): p. 936-940.
26. Li, X.-M., H. Ji, C.-J. Li, P.-H. Wang, P. Yu, and D.-M. Yu, Chemerin expression in Chinese pregnant women with and without gestational diabetes mellitus. Annales d'Endocrinologie, 2015. 76(1): p. 19-24.
27. Sun, J., J. Ren, C. Zuo, D. Deng, F. Pan, R. Chen, et al., Circulating apelin, chemerin and omentin levels in patients with gestational diabetes mellitus: A systematic review and meta-analysis. Lipids in health and disease, 2020. 19(1): p. 1-15.
28. Wang, D., H. Wang, M. Li, and R. Zhao, Chemerin levels and its genetic variants are associated with Gestational diabetes mellitus: A hospital-based study in a Chinese cohort. Gene, 2022. 807: p. 145888.
29. Hasanvand, Z., A. Sadeghi, M.R. Rezvanfar, M.T. Goodarzi, G. Rahmannezhad, and F.J. Mashayekhi, Association between chemerin rs17173608 and rs4721 gene polymorphisms and gestational diabetes mellitus in Iranian pregnant women. Gene, 2018. 649: p. 87-92.
30. Fatima, S.S., K. Bozaoglu, R. Rehman, F. Alam, and A.S. Memon, Elevated chemerin levels in Pakistani men: an interrelation with metabolic syndrome phenotypes. PloS one, 2013. 8(2): p. e57113.
31. Alverti, K., Metabolic syndrome: A new world-wide definition: A consensus statement from the International Diabetes Federation. Diabet Med, 2006. 23: p. 469-480.
32. O'Neill, S. and L. O'Driscoll, Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies. Obesity reviews, 2015. 16(1): p. 1-12.
33. Zahra Barmoudeh , M.H.S., Hossein Pourghadamyari , Mina Rohani Borj , Amir Hossein Doustimotlagh , Kazem Abbaszadeh-Goudarzi, C1q tumor necrosis factor related proteins (CTRPs) in patients with cardiovascular diseases
Acta Biochimica Iranica, 2023. 1(1): p. 12-19.
34. Batista, A., K. Barbosa, C. Masioli, E. Queiroz, C. Marinho, A. Cândido, et al., High levels of chemerin associated with variants in the NOS3 and APOB genes in rural populations of Ouro Preto, Minas Gerais, Brazil. Brazilian Journal of Medical and Biological Research, 2020. 53.
35. Hashemi, M., H. Rezaei, E. Eskandari-Nasab, M.A. kaykhaei, Z. Zakeri, and M. Taheri, Association between chemerin rs17173608 and vaspin rs2236242 gene polymorphisms and the metabolic syndrome, a preliminary report. Gene, 2012. 510(2): p. 113-117.
36. Mehanna, E.T., N.M. Mesbah, M.H. Ghattas, S.M. Saleh, and D.M. Abo-Elmatty, Association of chemerin Rs17173608 and vaspin Rs2236242 gene polymorphisms with metabolic syndrome in Egyptian women. Endocrine research, 2016. 41(1): p. 43-48.
37. Helvaci, N., N.D. Eyupoglu, E. Karabulut, and B.O. Yildiz, Prevalence of obesity and its impact on outcome in patients with COVID-19: a systematic review and meta-analysis. Frontiers in Endocrinology, 2021. 12: p. 598249.
38. Roya Jahangard , S.S.S.E., Akram Vatannejad, Reza Meshkani Autophagy protects peripheral blood mononuclear cells from high glucose-induced inflammation and apoptosis. Acta Biochimica Iranica, 2023. 1(1): p. 40-49.
39. Zhao, C., W. Hu, Y. Xu, D. Wang, Y. Wang, W. Lv, et al., Current Landscape: The Mechanism and Therapeutic Impact of Obesity for Breast Cancer. Front Oncol, 2021. 11: p. 704893.
40. Becer, E. and A. Çırakoğlu, Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 gene on lipid profile and adipokines levels in obese subjects. Balkan Journal of Medical Genetics, 2017. 20(1): p. 71-80.
41. Kohan, L., Z. Movahed, and O. Tabiee, Association between chemerin rs17173608 polymorphism and obesity in Iranian women. Int J Biosci, 2014. 4: p. 166-171.
42. Yun, Z., Y. Yu-Ping, T. Zong-Wu, S. Yang, Y. Fang, and S. Fang, Association of endothelial nitric oxide synthase gene polymorphisms with end-stage renal disease: a systematic review and meta-analysis. Renal Failure, 2014. 36(6): p. 987-993.
43. Xue, C., W. Nie, D. Tang, L. Yi, and C. Mei, Apolipoprotein E gene variants on the risk of end stage renal disease. PLoS One, 2013. 8(12): p. e83367.
44. Nomani, H., H. Khanmohamadian, A. Vaisi-Raygani, E. Shakiba, M. Tanhapour, and Z. Rahimi, Chemerin rs17173608 and vaspin rs2236242 gene variants on the risk of end stage renal disease (ESRD) and correlation with plasma malondialdehyde (MDA) level. Renal failure, 2018. 40(1): p. 350-356.
45. Leiherer, A., A. Muendlein, E. Kinz, A. Vonbank, P. Rein, P. Fraunberger, et al., High plasma chemerin is associated with renal dysfunction and predictive for cardiovascular events — Insights from phenotype and genotype characterization. Vascular Pharmacology, 2016. 77: p. 60-68.
46. Khaled, Y. and L. Rashed, Serum chemerin levels and chemerin rs17173608 genotypes in the susceptibility of diabetic nephropathy in Egyptian diabetic patients. Egyptian Journal of Obesity, Diabetes and Endocrinology, 2016. 2(1): p. 18.
47. Gruzdeva, O., E. Uchasova, Y. Dyleva, D. Borodkina, O. Akbasheva, L. Antonova, et al., Adipocytes directly affect coronary artery disease pathogenesis via induction of adipokine and cytokine imbalances. Frontiers in immunology, 2019. 10: p. 2163.
48. Wu, Q., Y. Chen, S. Chen, X. Wu, and W. Nong, Correlation between adiponectin, chemerin, vascular endothelial growth factor and epicardial fat volume in patients with coronary artery disease. Experimental and Therapeutic Medicine, 2020. 19(2): p. 1095-1102.
49. Er, L.-K., S. Wu, L.-A. Hsu, M.-S. Teng, Y.-C. Sun, and Y.-L. Ko, Pleiotropic Associations of RARRES2 Gene Variants and Circulating Chemerin Levels: Potential Roles of Chemerin Involved in the Metabolic and Inflammation-Related Diseases. Mediators of Inflammation, 2018. 2018: p. 4670521.
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2. Adeli, K., A Journey Forward: Acta Biochimica Iranica’s Rebirth and its Impact on the Evolution of Clinical Laboratory Sciences. Acta Biochimica Iranica, 2023. 1(1): p. 1-2.
3. Wittamer, V., F. Grégoire, P. Robberecht, G. Vassart, D. Communi, and M. Parmentier, The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency. Journal of Biological Chemistry, 2004. 279(11): p. 9956-9962.
4. Ben Dhaou, C., K. Mandi, M. Frye, A. Acheampong, A. Radi, B. De Becker, et al., Chemerin regulates normal angiogenesis and hypoxia-driven neovascularization. Angiogenesis, 2022. 25(2): p. 159-179.
5. Perumalsamy, S., N. Ain Aqilah Mohd Zin, R. Teguh Widodo, W. Azman Wan Ahmad, R.D. Vethakkan, and H. Zaman Huri, Chemokine like receptor-1 (CMKLR-1) receptor: a potential therapeutic target in management of chemerin induced type 2 diabetes mellitus and cancer. Current pharmaceutical design, 2017. 23(25): p. 3689-3698.
6. Nima Taghizadeh , S.M., Vahid Saeedi, Ladan Haghighi, Mona Nourbakhsh, Mitra Nourbakhsh, Maryam Razzaghy Azar, Association between Steroid Hormones and Insulin Resistance in Patients with Polycystic Ovary Syndrome. Acta Biochimica Iranica, 2023. 1(1): p. 26-31.
7. Dubois-Vedrenne, I., D. Al Delbany, O. De Henau, V. Robert, M. Vernimmen, F. Langa, et al., The antitumoral effects of chemerin are independent from leukocyte recruitment and mediated by inhibition of neoangiogenesis. Oncotarget, 2021. 12(19): p. 1903-1919.
8. Shin, W.J., B.A. Zabel, and R.K. Pachynski, Mechanisms and functions of chemerin in cancer: potential roles in therapeutic intervention. Frontiers in immunology, 2018. 9: p. 2772.
9. Nagpal, S., S. Patel, H. Jacobe, D. DiSepio, C. Ghosn, M. Malhotra, et al., Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene in skin. Journal of Investigative Dermatology, 1997. 109(1): p. 91-95.
10. Ernst, M.C. and C.J. Sinal, Chemerin: at the crossroads of inflammation and obesity. Trends in Endocrinology & Metabolism, 2010. 21(11): p. 660-667.
11. Chang, S.S., D. Eisenberg, L. Zhao, C. Adams, R. Leib, J. Morser, et al., Chemerin activation in human obesity. Obesity, 2016. 24(7): p. 1522-1529.
12. Mlyczyńska, E., M. Kieżun, P. Kurowska, M. Dawid, K. Pich, N. Respekta, et al., New Aspects of Corpus Luteum Regulation in Physiological and Pathological Conditions: Involvement of Adipokines and Neuropeptides. Cells, 2022. 11(6): p. 957.
13. Eichelmann, F., M.B. Schulze, C. Wittenbecher, J. Menzel, C. Weikert, R. di Giuseppe, et al., Association of chemerin plasma concentration with risk of colorectal cancer. JAMA network open, 2019. 2(3): p. e190896-e190896.
14. Helfer, G. and Q.-F. Wu, Chemerin: a multifaceted adipokine involved in metabolic disorders. Journal of Endocrinology, 2018. 238(2): p. R79-R94.
15. Zhao, K., W. Ding, Y. Zhang, K. Ma, D. Wang, C. Hu, et al., Variants in the RARRES2 gene are associated with serum chemerin and increase the risk of diabetic kidney disease in type 2 diabetes. International Journal of Biological Macromolecules, 2020. 165: p. 1574-1580.
16. Léniz, A., M. González, I. Besné, H. Carr-Ugarte, I. Gómez- García, and M.P. Portillo, Role of chemerin in the control of glucose homeostasis. Molecular and Cellular Endocrinology, 2022. 541: p. 111504.
17. Er, L.K., L.A. Hsu, J.J. Juang, F.T. Chiang, M.S. Teng, I.S. Tzeng, et al., Circulating Chemerin Levels, but not the RARRES2 Polymorphisms, Predict the Long-Term Outcome of Angiographically Confirmed Coronary Artery Disease. Int J Mol Sci, 2019. 20(5).
18. Zheng, Q., J. Jiang, Y. Huo, and D. Chen, Genetic predisposition to type 2 diabetes is associated with severity of coronary artery disease in patients with acute coronary syndromes. Cardiovasc Diabetol, 2019. 18(1): p. 131.
19. Dahpy, M.A., M.K. Khairallah, N.M.A. Azoz, and G.M. Ezzat, The associations among RARRES2 rs17173608 gene polymorphism, serum chemerin, and non-traditional lipid profile in patients with metabolic syndrome. Egyptian Journal of Medical Human Genetics, 2020. 21(1): p. 1-13.
20. Olt, S., O. Öznas, H. Bağış, and E.T. Turanlı, Chemerin rs17173608 Gene Polymorphism is not Associated with Type 2 Diabetes Mellitus: a Cross-sectional Study. Folia medica, 2019. 61(1): p. 69-75.
21. Abdelhamid, A.M. and M.A. Zaafan. Association of chemerin rs17173608 and vaspin rs2236242 polymorphisms with type two diabetes mellitus and its impact on their corresponding serum levels in Egyptian population. 2019. ideas.
22. Perumalsamy, S., W.A. Wan Ahmad, and H. Zaman Huri, Single Nucleotide Polymorphism rs17173608 in the Chemerin Encoding Gene: Is It a Predictor of Insulin Resistance and Severity of Coronary Artery Disease in Non-Obese Type 2 Diabetes? Healthcare, 2021. 9(6): p. 623.
23. Wang, H., N. Li, T. Chivese, M. Werfalli, H. Sun, L. Yuen, et al., IDF Diabetes Atlas: Estimation of Global and Regional Gestational Diabetes Mellitus Prevalence for 2021 by International Association of Diabetes in Pregnancy Study Group’s Criteria. Diabetes Research and Clinical Practice, 2022. 183: p. 109050.
24. Hamzeh Saberi , G.T., Reza Meshkani The ENPP1 K121Q polymorphism is associated with obesity-related parameters in Iranian normoglycemic male subjects. Acta Biochimica Iranica, 2023. 1(1): p. 20-25.
25. Hare, K., L. Bonde, J. Svare, H. Randeva, M. Asmar, S. Larsen, et al., Decreased plasma chemerin levels in women with gestational diabetes mellitus. Diabetic Medicine, 2014. 31(8): p. 936-940.
26. Li, X.-M., H. Ji, C.-J. Li, P.-H. Wang, P. Yu, and D.-M. Yu, Chemerin expression in Chinese pregnant women with and without gestational diabetes mellitus. Annales d'Endocrinologie, 2015. 76(1): p. 19-24.
27. Sun, J., J. Ren, C. Zuo, D. Deng, F. Pan, R. Chen, et al., Circulating apelin, chemerin and omentin levels in patients with gestational diabetes mellitus: A systematic review and meta-analysis. Lipids in health and disease, 2020. 19(1): p. 1-15.
28. Wang, D., H. Wang, M. Li, and R. Zhao, Chemerin levels and its genetic variants are associated with Gestational diabetes mellitus: A hospital-based study in a Chinese cohort. Gene, 2022. 807: p. 145888.
29. Hasanvand, Z., A. Sadeghi, M.R. Rezvanfar, M.T. Goodarzi, G. Rahmannezhad, and F.J. Mashayekhi, Association between chemerin rs17173608 and rs4721 gene polymorphisms and gestational diabetes mellitus in Iranian pregnant women. Gene, 2018. 649: p. 87-92.
30. Fatima, S.S., K. Bozaoglu, R. Rehman, F. Alam, and A.S. Memon, Elevated chemerin levels in Pakistani men: an interrelation with metabolic syndrome phenotypes. PloS one, 2013. 8(2): p. e57113.
31. Alverti, K., Metabolic syndrome: A new world-wide definition: A consensus statement from the International Diabetes Federation. Diabet Med, 2006. 23: p. 469-480.
32. O'Neill, S. and L. O'Driscoll, Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies. Obesity reviews, 2015. 16(1): p. 1-12.
33. Zahra Barmoudeh , M.H.S., Hossein Pourghadamyari , Mina Rohani Borj , Amir Hossein Doustimotlagh , Kazem Abbaszadeh-Goudarzi, C1q tumor necrosis factor related proteins (CTRPs) in patients with cardiovascular diseases
Acta Biochimica Iranica, 2023. 1(1): p. 12-19.
34. Batista, A., K. Barbosa, C. Masioli, E. Queiroz, C. Marinho, A. Cândido, et al., High levels of chemerin associated with variants in the NOS3 and APOB genes in rural populations of Ouro Preto, Minas Gerais, Brazil. Brazilian Journal of Medical and Biological Research, 2020. 53.
35. Hashemi, M., H. Rezaei, E. Eskandari-Nasab, M.A. kaykhaei, Z. Zakeri, and M. Taheri, Association between chemerin rs17173608 and vaspin rs2236242 gene polymorphisms and the metabolic syndrome, a preliminary report. Gene, 2012. 510(2): p. 113-117.
36. Mehanna, E.T., N.M. Mesbah, M.H. Ghattas, S.M. Saleh, and D.M. Abo-Elmatty, Association of chemerin Rs17173608 and vaspin Rs2236242 gene polymorphisms with metabolic syndrome in Egyptian women. Endocrine research, 2016. 41(1): p. 43-48.
37. Helvaci, N., N.D. Eyupoglu, E. Karabulut, and B.O. Yildiz, Prevalence of obesity and its impact on outcome in patients with COVID-19: a systematic review and meta-analysis. Frontiers in Endocrinology, 2021. 12: p. 598249.
38. Roya Jahangard , S.S.S.E., Akram Vatannejad, Reza Meshkani Autophagy protects peripheral blood mononuclear cells from high glucose-induced inflammation and apoptosis. Acta Biochimica Iranica, 2023. 1(1): p. 40-49.
39. Zhao, C., W. Hu, Y. Xu, D. Wang, Y. Wang, W. Lv, et al., Current Landscape: The Mechanism and Therapeutic Impact of Obesity for Breast Cancer. Front Oncol, 2021. 11: p. 704893.
40. Becer, E. and A. Çırakoğlu, Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 gene on lipid profile and adipokines levels in obese subjects. Balkan Journal of Medical Genetics, 2017. 20(1): p. 71-80.
41. Kohan, L., Z. Movahed, and O. Tabiee, Association between chemerin rs17173608 polymorphism and obesity in Iranian women. Int J Biosci, 2014. 4: p. 166-171.
42. Yun, Z., Y. Yu-Ping, T. Zong-Wu, S. Yang, Y. Fang, and S. Fang, Association of endothelial nitric oxide synthase gene polymorphisms with end-stage renal disease: a systematic review and meta-analysis. Renal Failure, 2014. 36(6): p. 987-993.
43. Xue, C., W. Nie, D. Tang, L. Yi, and C. Mei, Apolipoprotein E gene variants on the risk of end stage renal disease. PLoS One, 2013. 8(12): p. e83367.
44. Nomani, H., H. Khanmohamadian, A. Vaisi-Raygani, E. Shakiba, M. Tanhapour, and Z. Rahimi, Chemerin rs17173608 and vaspin rs2236242 gene variants on the risk of end stage renal disease (ESRD) and correlation with plasma malondialdehyde (MDA) level. Renal failure, 2018. 40(1): p. 350-356.
45. Leiherer, A., A. Muendlein, E. Kinz, A. Vonbank, P. Rein, P. Fraunberger, et al., High plasma chemerin is associated with renal dysfunction and predictive for cardiovascular events — Insights from phenotype and genotype characterization. Vascular Pharmacology, 2016. 77: p. 60-68.
46. Khaled, Y. and L. Rashed, Serum chemerin levels and chemerin rs17173608 genotypes in the susceptibility of diabetic nephropathy in Egyptian diabetic patients. Egyptian Journal of Obesity, Diabetes and Endocrinology, 2016. 2(1): p. 18.
47. Gruzdeva, O., E. Uchasova, Y. Dyleva, D. Borodkina, O. Akbasheva, L. Antonova, et al., Adipocytes directly affect coronary artery disease pathogenesis via induction of adipokine and cytokine imbalances. Frontiers in immunology, 2019. 10: p. 2163.
48. Wu, Q., Y. Chen, S. Chen, X. Wu, and W. Nong, Correlation between adiponectin, chemerin, vascular endothelial growth factor and epicardial fat volume in patients with coronary artery disease. Experimental and Therapeutic Medicine, 2020. 19(2): p. 1095-1102.
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| Files | ||
| Issue | Vol 1 No 2 (2023) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/abi.v1i2.14102 | |
| Keywords | ||
| Chemerin gene polymorphism diabetes adipokines | ||
| Rights and permissions | |
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Mazloomi S, Goodarzi MT. The Relationship Between Chemerin Gene Polymorphism and the Incidence of Various Diseases. ABI. 2023;1(2):65-70.
