Original Articles

Development and Optimization of Chamomile Extract Pastilles for Potential Oral Ulcer Treatment

Abstract

Objectives: This study aimed to develop and optimize chamomile extract pastilles as a potential therapeutic option for oral ulcer treatment, focusing on masking chamomile’s bitterness, ensuring stability, and achieving controlled release of active constituents to enhance patient compliance.

Materials: Chamomile (Matricaria chamomilla L.) extract was prepared via percolation using 80% ethanol. Pastilles were formulated with gelatin, xylitol, aspartame, citric acid, and flavoring agents (eucalyptus, lemon, raspberry, cola). Physical properties (smoothness, elasticity, color), sensory acceptability (rated by 10 volunteers), quercetin content (UV-Vis spectrophotometry), and dissolution profiles (in artificial saliva, pH 6.8) were assessed. Sensory scores were analyzed using one-way ANOVA with Tukey post-hoc tests (p < 0.05).

Results: Formulations J1 and J2, incorporating citric acid, exhibited significantly higher sensory scores (p < 0.0001) than G1–G3, effectively masking bitterness. Quercetin content indicated 85–89% loading efficiency across formulations. Dissolution tests showed controlled release of chamomile extract from J2 pastilles compared to pure extract, with stable release over 60 minutes. Physical assessments confirmed smooth, cohesive pastilles with favorable elasticity.

Conclusion: Chamomile extract pastilles represent a promising formulation with potential for oral ulcer treatment, offering improved palatability and controlled release. Their natural composition and high acceptability suggest potential for pediatric and adult use, warranting further clinical trials to validate efficacy and long-term stability.

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SectionOriginal Articles
DOI https://doi.org/10.18502/abi.v3i1.19348
Keywords
Chamomile oral ulcers pastilles herbal therapeutics formulation
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How to Cite
1.
Javaherchian P, Azimzadeh M, Azimzadeh F. Development and Optimization of Chamomile Extract Pastilles for Potential Oral Ulcer Treatment. ABI. 2025;3(1):30-35.