Tehran University of Medical Sciences Acta Biochimica Iranica 0001-5261 2 1 2024 03 22 36 44 Behrooz Ghezelbash Laboratory Hematology and Blood Banking, School of Allied Medical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. Marjan Golabi Department of Immunology, Faculty of Medicine, Isfahan University of Medical Science, Isfahan, Iran Negah Tavakol Department of Community Medicine, School of Medicine, Isfahan, Iran Azam Mesgari Isfahan Regional Educational Blood Transfusion Center, Isfahan University of Medical Science, Isfahan, Iran. Reihaneh Shamsfar Isfahan Regional Educational Blood Transfusion Center, Isfahan University of Medical Science, Isfahan, Iran. Ramin Sami Department of Internal Medicine, School of Medicine, Khorshid Hospital, Isfahan University of Medical Science, Isfahan, Iran Isfahan, Iran. Nahid Eskandari Department of Immunology, Faculty of Medicine, Isfahan University of Medical Science, Isfahan, Iran 2024 05 22 Objective: Over 50 million confirmed cases and 1.5 million fatalities worldwide have been linked to the COVID-19 pandemic. Researchers have used convalescent plasma (CP) from recovered patients, including neutralizing antibodies, to develop therapeutics for virus neutralization and prevention. This study assessed the effectiveness of CP by using several clinical and laboratory variables. Methods: The intervention group received two doses of CP on the day of hospitalization, while the control group received standard care. Clinical and analytical data were documented and evaluated before plasma therapy and on the third and fifth days after therapy. The results included measurements were measured in the patient's blood using the ELISA method. Results: The present study showed that the ICU hospitalization times for the control and CP groups were similar, with a slightly lower mortality rate in the CP group (6.2% vs. 8.2%, p > 0.05). There was no significant association between COVID-19 and clinical factors such as blood pressure, heart rate (HR), respiration rate (RR), and temperature. The blood serum urea, serum LDH, ALT, PTT, PLT, and IL-6 were significantly higher in the CP group than in the control group (p <0.05). Our results indicated that there was no difference in blood pH, PO2, HCO3, ESR, WBC counts, serum troponin, Na, AST, CRP, D-dimer, and PT between patients in the CP and control groups. Conclusion: Overall, in certain instances, CP therapy may help individuals with covid-19 recover. In general, additional research is required to determine the efficacy of plasma treatment in COVID-19 patient care. https://abi.tums.ac.ir/index.php/abi/article/view/85 https://abi.tums.ac.ir/index.php/abi/article/download/85/50