Tehran University of Medical Sciences Acta Biochimica Iranica 0001-5261 2 1 2024 03 22 4 10 Ali Akbar Soleimani Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Behnam Omidi Sarajar Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Masoume Aliabadi Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. Marzyeh Azmon Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Reza Meshkani Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 2024 05 22   A large amount of research suggests that polyphenols may have health benefits, particularly in metabolic disorders associated with obesity, such as non-alcoholic fatty liver (NAFLD), type 2 diabetes, and cardiovascular disease. Because of the importance of oxidative stress in the pathogenesis of metabolic disorders, great emphasis has recently been paid to the characteristics of polyphenols in obesity-related problems. This narrative review summarizes the current knowledge on the inhibitory effects of polyphenols, including curcumin, resveratrol, baicalin, nobiletin, and quercetin, on oxidative stress by focusing on the role of the Nrf2 pathway. This review gathered the data of the articles showing that the aforementioned polyphenols improve health in metabolic diseases via regulating Nrf2 and its target proteins involved in ameliorating oxidative stress. However, due to the limitations of in vitro and in vivo investigations, as well as lack of long-term human clinical trial trials studies, further high-quality research is required to definitively show polyphenols’ clinical usefulness for the prevention and management of NAFLD. https://abi.tums.ac.ir/index.php/abi/article/view/83 https://abi.tums.ac.ir/index.php/abi/article/download/83/45