Tehran University of Medical Sciences Acta Biochimica Iranica 0001-5261 1 3 2023 12 01 The Emerging role of MALAT1 lncRNA in diabetic nephropathy: based on the review of the literature and bioinformatic analysis 105 111 Shekoofeh Nikooei Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran Erfan Azadifar Department of Laboratory Sciences, Faculty of Paramedicine, Yasuj University of Medical Sciences, Yasuj, Iran. Behnam Alipoor Department of Laboratory Sciences, Faculty of Paramedicine, Yasuj University of Medical Sciences, Yasuj, Iran. 2023 12 21 Previous studies have found that the metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) exerts its biological effects on the progression of diabetic nephropathy by sponging microRNAs and affecting the gene transcription of downstream molecules. In this study, the primary emphasis is placed on the functions that MALAT1 plays in relation to the pathophysiology of diabetic nephropathy as well as the processes that underlie these roles. In addition, the usage of this long noncoding RNA as a possible biomarker or therapeutic target for diabetic nephropathy will be discussed. https://abi.tums.ac.ir/index.php/abi/article/view/46 https://abi.tums.ac.ir/index.php/abi/article/download/46/22