Tehran University of Medical Sciences Acta Biochimica Iranica 0001-5261 3 4 2025 12 20 197 205 Tooba Yousefi Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Samira Nomiri Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Reyhaneh Taebi Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Farzaneh Yazdanimoghaddam Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Yaser Mohammadi Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. 2025 12 22 2026 01 05 Prosopis farcta, a medicinal plant of the Fabaceae family, is being explored scientifically on the basis of its diverse biological activities and medicinal importance. Rich in flavonoids, alkaloids, and phenolics, P. farcta exhibits strong antioxidant, anti-inflammatory, antimicrobial, and hepatoprotective activities. It has been demonstrated that it can exert neuroprotection by modulating oxidative stress and inflammatory pathways. Further, P. farcta possesses antidiabetic activity through the facilitation of the insulin sensitivity and glucose metabolism, and hence it is a good candidate for glycemic control. Its wound healing efficacy via the anti-inflammatory and antimicrobial activities has been studied through in-vivo and in-vitro models. P. farcta also possesses cardioprotective activity via lipid metabolism modulation and improvement of endothelial function. Nevertheless, while P. farcta fruit extracts have hepatoprotective effects, evidence further suggests the potential for hepatotoxicity with its seed extract, emphasizing dose-dependent analysis. Despite its therapeutic pharmacological potential, additional clinical trials must determine its safety profile, define its optimal therapeutic dosages, and clarify its particular molecular mechanisms of the action. This review consolidates the current evidence in support of the medicinal worth of P. farcta, demonstrating its applications in modern medicine. https://abi.tums.ac.ir/index.php/abi/article/view/173 https://abi.tums.ac.ir/index.php/abi/article/download/173/122