Tehran University of Medical Sciences Acta Biochimica Iranica 0001-5261 3 1 2025 03 26 46 54 Marzieh Dehghan Shasaltaneh Department of Biology, Faculty of Science, University of Zanjan, Zanjan, Iran Sadrollah Ramezani University of Sistan and Baluchestan, Zahedan, Iran. Nasser Naghdi Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran Gholam Hossein Riazi Laboratory of Neuro-organic Chemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran. 2025 05 12 2025 06 28 Objectives: Learning and memory retention are processes that involve a permanent change in the behavior based on environmental adaptation. Reelin protein participates in the learning and memory. It has not received much attention in the presence of herbal components. The present study focused on the effect of an optimum dose of Beta-Boswellic Acid (BBA) on the reduction of tau phosphorylation level and enhancement of Reelin expression on the hippocampus regions to improve cognitive behavioural therapy. Methods: Spatial memory, learning, and locomotor activity were assessed. The histological analysis was performed. The Western blot analysis was employed. Results: The results represented the significant effect of BBA (35 mg/kg of body weight) on the degree of memory consolidation in the probe trial of MWM test. The BBA treatment reduced dark neuron formation in the hippocampus. This component promoted the Reelin expression. Conclusion: A certain dose of BBA improved memory consolidation in the adult rats, and Reelin protein was more expressed in the presence of BBA that it may be due to the anti-inflammatory property of BBA as one of the main factors involved in enhancing memory consolidation among rats. https://abi.tums.ac.ir/index.php/abi/article/view/111 https://abi.tums.ac.ir/index.php/abi/article/download/111/101